The Effects of Nootropic Drugs on Striatal 5-HT2A-Receptors in Outbred Mice with Different Efficacy of Exploratory Behavior
Resume. The effect of subchronic administration of nootropic drugs of different structures (piracetam 200 mg/kg/day, pantocalcin 200 mg/kg/day, semax 0.6 mg/ kg/day, nooglutil 50 mg/kg/day) to mice of the outbred line 1CR on spontaneous research activity in a closed cross-maze and on the binding cha...
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| Language: | Russian |
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2019-10-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/69 |
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| author | Yu. Yu. Firstova E. V. Vasileva G. I. Kovalev |
| author_facet | Yu. Yu. Firstova E. V. Vasileva G. I. Kovalev |
| author_sort | Yu. Yu. Firstova |
| collection | DOAJ |
| description | Resume. The effect of subchronic administration of nootropic drugs of different structures (piracetam 200 mg/kg/day, pantocalcin 200 mg/kg/day, semax 0.6 mg/ kg/day, nooglutil 50 mg/kg/day) to mice of the outbred line 1CR on spontaneous research activity in a closed cross-maze and on the binding characteristics of 5-HT2A-receptors in striatal membranes. In experiments using [3H] (+)Ketanserin, it has been established that the mice brains exhibiting a low efficacy of exploratory behavior (LEEB) in the closed cross-maze test has a lower density of 5-HT2A receptors (Bmax = 519 ± 13 fmol/ mg , p = 0.02) in comparison with the subpopulation with high efficacy of exploratory behavior (HEEB) (639 ± 48 fmol / mg). After 5-fold administration of nootropics, only in groups with LEEB there was a significant increase in the Bmax value under the action of all investigated nootropics: piracetam (643 ± 42 fmol/mg); pantocalcine (662 ± 29 fmol/mg); semax (742 ± 29 fmol/mg) and nooglutil (1145 fmol/mg) at p = 0.01. By the Kd value, the subpopulations did not initially differ and did not undergo significant changes under the action of the drugs. The presence of serotonin-positive effects of all drugs studied in animals with initially reduced receptor density is consistent with the hypothesis of the selective, modulating nature of the nootropics action. |
| format | Article |
| id | doaj-art-7669db8c228645fd95d101d3322b01ac |
| institution | DOAJ |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2019-10-01 |
| publisher | LLC “Publisher OKI” |
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| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-7669db8c228645fd95d101d3322b01ac2025-08-20T02:49:53ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302019-10-0103424710.24411/2587-7836-2018-10023.68The Effects of Nootropic Drugs on Striatal 5-HT2A-Receptors in Outbred Mice with Different Efficacy of Exploratory BehaviorYu. Yu. Firstova0E. V. Vasileva1G. I. Kovalev2FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»Resume. The effect of subchronic administration of nootropic drugs of different structures (piracetam 200 mg/kg/day, pantocalcin 200 mg/kg/day, semax 0.6 mg/ kg/day, nooglutil 50 mg/kg/day) to mice of the outbred line 1CR on spontaneous research activity in a closed cross-maze and on the binding characteristics of 5-HT2A-receptors in striatal membranes. In experiments using [3H] (+)Ketanserin, it has been established that the mice brains exhibiting a low efficacy of exploratory behavior (LEEB) in the closed cross-maze test has a lower density of 5-HT2A receptors (Bmax = 519 ± 13 fmol/ mg , p = 0.02) in comparison with the subpopulation with high efficacy of exploratory behavior (HEEB) (639 ± 48 fmol / mg). After 5-fold administration of nootropics, only in groups with LEEB there was a significant increase in the Bmax value under the action of all investigated nootropics: piracetam (643 ± 42 fmol/mg); pantocalcine (662 ± 29 fmol/mg); semax (742 ± 29 fmol/mg) and nooglutil (1145 fmol/mg) at p = 0.01. By the Kd value, the subpopulations did not initially differ and did not undergo significant changes under the action of the drugs. The presence of serotonin-positive effects of all drugs studied in animals with initially reduced receptor density is consistent with the hypothesis of the selective, modulating nature of the nootropics action.https://www.pharmacokinetica.ru/jour/article/view/69ноотропы5-нт<sub>2а</sub>-рецепторы[g-<sup>3</sup>н](+)кетансеринпирацетамнооглютилсемакспантокальцинстриатумкрестообразный лабиринтисследовательское поведениеnootropics5-ht<sub>2a</sub>-receptors[g-<sup>3</sup>h] (+) ketanserinpiracetamnooglutilsemaxpantocalcinestriatumclosed cross-mazeexploratory behavior |
| spellingShingle | Yu. Yu. Firstova E. V. Vasileva G. I. Kovalev The Effects of Nootropic Drugs on Striatal 5-HT2A-Receptors in Outbred Mice with Different Efficacy of Exploratory Behavior Фармакокинетика и Фармакодинамика ноотропы 5-нт<sub>2а</sub>-рецепторы [g-<sup>3</sup>н](+)кетансерин пирацетам нооглютил семакс пантокальцин стриатум крестообразный лабиринт исследовательское поведение nootropics 5-ht<sub>2a</sub>-receptors [g-<sup>3</sup>h] (+) ketanserin piracetam nooglutil semax pantocalcine striatum closed cross-maze exploratory behavior |
| title | The Effects of Nootropic Drugs on Striatal 5-HT2A-Receptors in Outbred Mice with Different Efficacy of Exploratory Behavior |
| title_full | The Effects of Nootropic Drugs on Striatal 5-HT2A-Receptors in Outbred Mice with Different Efficacy of Exploratory Behavior |
| title_fullStr | The Effects of Nootropic Drugs on Striatal 5-HT2A-Receptors in Outbred Mice with Different Efficacy of Exploratory Behavior |
| title_full_unstemmed | The Effects of Nootropic Drugs on Striatal 5-HT2A-Receptors in Outbred Mice with Different Efficacy of Exploratory Behavior |
| title_short | The Effects of Nootropic Drugs on Striatal 5-HT2A-Receptors in Outbred Mice with Different Efficacy of Exploratory Behavior |
| title_sort | effects of nootropic drugs on striatal 5 ht2a receptors in outbred mice with different efficacy of exploratory behavior |
| topic | ноотропы 5-нт<sub>2а</sub>-рецепторы [g-<sup>3</sup>н](+)кетансерин пирацетам нооглютил семакс пантокальцин стриатум крестообразный лабиринт исследовательское поведение nootropics 5-ht<sub>2a</sub>-receptors [g-<sup>3</sup>h] (+) ketanserin piracetam nooglutil semax pantocalcine striatum closed cross-maze exploratory behavior |
| url | https://www.pharmacokinetica.ru/jour/article/view/69 |
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