Antiretroviral therapy initiated during acute infection in women with HIV-1 clade C reduces anti-Tat antibody production and lowers CD8+ T cell activation

Antiretroviral therapy initiated during acute infection in women with HIV-1 clade C reduces anti-Tat antibody production and lowers CD8+ T cell activation

IntroductionThe HIV-1 Tat protein is essential for virus replication and spread and is therefore a potential target for anti-HIV therapy. Anti-Tat antibodies have been shown to slow HIV disease progression and improve antiretroviral therapy (ART) efficacy. Long-term ART results in partial reconstitu...

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Bibliographic Details
Main Authors: Thandeka I. Kubheka, Kewreshini Naidoo, Kavidha Reddy, Thumbi Ndung’u, Nompumelelo P. Mkhwanazi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
ART
HIV-1 Tat
Tat antibodies
early treated HIV
ELISA - enzyme-linked immunosorbent assay
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564960/full
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