Assessing drug-drug interactions of Tacrolimus with Fluconazole and/or Verapamil and developing the predictive model for Tacrolimus concentrations in kidney transplant recipients

Assessing drug-drug interactions of Tacrolimus with Fluconazole and/or Verapamil and developing the predictive model for Tacrolimus concentrations in kidney transplant recipients

Maintaining optimal tacrolimus serum concentrations is crucial for kidney transplant recipients due to its narrow therapeutic window and pharmacokinetic variability. The use of CYP3A4/5 inhibitors, such as fluconazole and verapamil, can increase tacrolimus serum concentrations. Understanding these i...

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Bibliographic Details
Main Authors: Mingkwan Na Takuathung, Kajohnsak Noppakun, Chotiwit Sakuludomkan, Nahathai Dukaew, Nuttapong Chailungkar, Naruemon Suyayai, Nut Koonrungsesomboon
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Transplantation Reports
Subjects:
Drug‐drug interaction
Fluconazole
Kidney transplantation
Tacrolimus
Verapamil
Online Access:http://www.sciencedirect.com/science/article/pii/S2451959625000058
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