SPP1+ TAM: CD8+ T Cell Crosstalk Associates with Blocking Radiotherapy Efficacy in Lung Cancer

SPP1+ TAM: CD8+ T Cell Crosstalk Associates with Blocking Radiotherapy Efficacy in Lung Cancer

Radiotherapy (RT) is a cornerstone treatment for non-small cell lung cancer (NSCLC), but its efficacy is often limited by immune suppression in the tumor microenvironment. In this study, we identified SPP1 as a key factor up-regulated after RT, mainly expressed by immunosuppressive macrophages. Sing...

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Bibliographic Details
Main Authors: Yuzhao Jin, Yuan Zhuang, Peng Luo, Xiaojie Zhang, Jinhua Luo, Yifei Ma, Dandan Guo, Na Hang, Qing Li, Zhijun Shen, Zhao Xie, Ruiqing Gao, Chenyu Gao, Ling Wang, Wenjun Mao, Bufu Tang, Songhua Cai
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2025-01-01
Series:Research
Online Access:https://spj.science.org/doi/10.34133/research.0851
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