Exosomal encapsulation of a steviol derivative SD9 to overcome TRAIL resistance as a highly effective therapy against lung cancer

Exosomal encapsulation of a steviol derivative SD9 to overcome TRAIL resistance as a highly effective therapy against lung cancer

Abstract Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a promising pro-apoptotic factor. However, it has showed very limited efficacies due to low bioavailability and common drug resistance in cancers. Extracellular vesicle delivery of TRAIL (EV-T) has significantly improv...

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Bibliographic Details
Main Authors: Quanjiang Li, Yufeng Xie, Wanting Zhang, Jun Peng, Zhujie Deng, Rui Tian, Xiubin Kuang, Bin Xie, Chen Huang, Yu Zhao, Zhengqiang Yuan
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cancer Nanotechnology
Subjects:
Steviol derivative
EV-T
Complexed nanodrug
TRAIL sensitization
Apoptosis
Online Access:https://doi.org/10.1186/s12645-025-00329-y
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