Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicine
As the population ages, intestinal health in the elderly has become a key area of concern, with gut microbiota dysbiosis emerging as a significant issue. This review summarizes the factors influencing dysbiosis and interventions from both traditional Chinese medicine (TCM) and Western medicine, offe...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1529347/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849394533774655488 |
|---|---|
| author | Zhi-Jun Zhang Ru Gao Yu-Tong Lu Zhi-Liang Zuo Zhi-Liang Zuo Yu-Huan Li Shan Liu Si-Yuan Song Yi Wang Hongyan Lai |
| author_facet | Zhi-Jun Zhang Ru Gao Yu-Tong Lu Zhi-Liang Zuo Zhi-Liang Zuo Yu-Huan Li Shan Liu Si-Yuan Song Yi Wang Hongyan Lai |
| author_sort | Zhi-Jun Zhang |
| collection | DOAJ |
| description | As the population ages, intestinal health in the elderly has become a key area of concern, with gut microbiota dysbiosis emerging as a significant issue. This review summarizes the factors influencing dysbiosis and interventions from both traditional Chinese medicine (TCM) and Western medicine, offering a reference for future research. A comprehensive search of global databases up to March 2024 identified 617 original studies on gut microbiota dysbiosis in individuals aged 65 and older. After applying strict PRISMA guidelines, 20 articles met the inclusion criteria. Key findings are summarized in four areas: 1) the definition and mechanisms of dysbiosis, 2) evaluation tools for gut microbiota imbalance, 3) factors contributing to dysbiosis in the elderly, and 4) pharmacological treatments. Both TCM and Western medicine offer unique advantages in managing gut microbiota dysbiosis, and the choice of intervention should be tailored to the individual’s condition. Future research should focus on optimizing integrated TCM and Western medicine approaches to improve outcomes for elderly patients with gut microbiota dysbiosis. |
| format | Article |
| id | doaj-art-765cd7f703d34571a498ed1e836f04bd |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-765cd7f703d34571a498ed1e836f04bd2025-08-20T03:39:57ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-03-011510.3389/fcimb.2025.15293471529347Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicineZhi-Jun Zhang0Ru Gao1Yu-Tong Lu2Zhi-Liang Zuo3Zhi-Liang Zuo4Yu-Huan Li5Shan Liu6Si-Yuan Song7Yi Wang8Hongyan Lai9Hepatological surgery department, The People’s Hospital of Wenjiang Chengdu, Chengdu, ChinaNursing Department, The People’s Hospital of Wenjiang Chengdu, Chengdu, ChinaNursing Department, The People’s Hospital of Wenjiang Chengdu, Chengdu, ChinaThe Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaCollege of Food Science and Engineering, Northwest A&F University, Yangling, ChinaNursing Department, The People’s Hospital of Wenjiang Chengdu, Chengdu, ChinaDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, United StatesDepartment of Critical Care Medicine, Sichuan Academy of Medical Science and Sichuan, Chengdu, ChinaChongqing Key Laboratory of Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, Chongqing, ChinaAs the population ages, intestinal health in the elderly has become a key area of concern, with gut microbiota dysbiosis emerging as a significant issue. This review summarizes the factors influencing dysbiosis and interventions from both traditional Chinese medicine (TCM) and Western medicine, offering a reference for future research. A comprehensive search of global databases up to March 2024 identified 617 original studies on gut microbiota dysbiosis in individuals aged 65 and older. After applying strict PRISMA guidelines, 20 articles met the inclusion criteria. Key findings are summarized in four areas: 1) the definition and mechanisms of dysbiosis, 2) evaluation tools for gut microbiota imbalance, 3) factors contributing to dysbiosis in the elderly, and 4) pharmacological treatments. Both TCM and Western medicine offer unique advantages in managing gut microbiota dysbiosis, and the choice of intervention should be tailored to the individual’s condition. Future research should focus on optimizing integrated TCM and Western medicine approaches to improve outcomes for elderly patients with gut microbiota dysbiosis.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1529347/fullelderlygut microbiota dysbiosisinfluencing factorstraditional Chinese medicine interventionWestern medicine interventionresearch progress |
| spellingShingle | Zhi-Jun Zhang Ru Gao Yu-Tong Lu Zhi-Liang Zuo Zhi-Liang Zuo Yu-Huan Li Shan Liu Si-Yuan Song Yi Wang Hongyan Lai Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicine Frontiers in Cellular and Infection Microbiology elderly gut microbiota dysbiosis influencing factors traditional Chinese medicine intervention Western medicine intervention research progress |
| title | Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicine |
| title_full | Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicine |
| title_fullStr | Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicine |
| title_full_unstemmed | Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicine |
| title_short | Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicine |
| title_sort | factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional chinese and western medicine |
| topic | elderly gut microbiota dysbiosis influencing factors traditional Chinese medicine intervention Western medicine intervention research progress |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1529347/full |
| work_keys_str_mv | AT zhijunzhang factorsaffectingdysbiosisofthegutmicrobiotaintheelderlyandtheprogressofinterventionsintraditionalchineseandwesternmedicine AT rugao factorsaffectingdysbiosisofthegutmicrobiotaintheelderlyandtheprogressofinterventionsintraditionalchineseandwesternmedicine AT yutonglu factorsaffectingdysbiosisofthegutmicrobiotaintheelderlyandtheprogressofinterventionsintraditionalchineseandwesternmedicine AT zhiliangzuo factorsaffectingdysbiosisofthegutmicrobiotaintheelderlyandtheprogressofinterventionsintraditionalchineseandwesternmedicine AT zhiliangzuo factorsaffectingdysbiosisofthegutmicrobiotaintheelderlyandtheprogressofinterventionsintraditionalchineseandwesternmedicine AT yuhuanli factorsaffectingdysbiosisofthegutmicrobiotaintheelderlyandtheprogressofinterventionsintraditionalchineseandwesternmedicine AT shanliu factorsaffectingdysbiosisofthegutmicrobiotaintheelderlyandtheprogressofinterventionsintraditionalchineseandwesternmedicine AT siyuansong factorsaffectingdysbiosisofthegutmicrobiotaintheelderlyandtheprogressofinterventionsintraditionalchineseandwesternmedicine AT yiwang factorsaffectingdysbiosisofthegutmicrobiotaintheelderlyandtheprogressofinterventionsintraditionalchineseandwesternmedicine AT hongyanlai factorsaffectingdysbiosisofthegutmicrobiotaintheelderlyandtheprogressofinterventionsintraditionalchineseandwesternmedicine |