Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles
In imaging, contrast agents are utilized to enhance sensitivity and specificity of diagnostic modalities. In ultrasound imaging, microbubbles (MBs)—a gas-core shell-encapsulated agent—are used clinically as contrast agents. The working hypothesis of this study is that microbubbles can be employed as...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/2014/471764 |
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| author | Homa Assadi Raffi Karshafian Alexandre Douplik |
| author_facet | Homa Assadi Raffi Karshafian Alexandre Douplik |
| author_sort | Homa Assadi |
| collection | DOAJ |
| description | In imaging, contrast agents are utilized to enhance sensitivity and specificity of diagnostic modalities. In ultrasound imaging, microbubbles (MBs)—a gas-core shell-encapsulated agent—are used clinically as contrast agents. The working hypothesis of this study is that microbubbles can be employed as an intravascular contrast agent in optical imaging systems. In this work, the interaction of light and microbubbles in a turbid medium (intralipid) was investigated, particularly, the effect of MBs on the reduced scattering and absorption coefficients. Diffuse reflectance (DR) and total transmittance (TT) measurements of highly scattering intralipid suspension (0.5–5%) were measured using spectroscopic integrating sphere system in the absence and presence of Definity microbubbles. The optical properties were computed using the inverse adding doubling (IAD) software. The presence of microbubbles increased DR and decreased TT of intralipid phantoms. In the presence of MBs (0.5% volume concentration), the reflectance of the intralipid phantom increased from 35% to 100%. The reduced scattering coefficient increased significantly (30%) indicating potential use of MBs as optical contrast agents in light based modalities. |
| format | Article |
| id | doaj-art-765b4046bfca43d0aac92cdc1282f10d |
| institution | Kabale University |
| issn | 1110-662X 1687-529X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-765b4046bfca43d0aac92cdc1282f10d2025-08-20T03:35:18ZengWileyInternational Journal of Photoenergy1110-662X1687-529X2014-01-01201410.1155/2014/471764471764Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated MicrobubblesHoma Assadi0Raffi Karshafian1Alexandre Douplik2Department of Physics, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, CanadaDepartment of Physics, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, CanadaDepartment of Physics, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, CanadaIn imaging, contrast agents are utilized to enhance sensitivity and specificity of diagnostic modalities. In ultrasound imaging, microbubbles (MBs)—a gas-core shell-encapsulated agent—are used clinically as contrast agents. The working hypothesis of this study is that microbubbles can be employed as an intravascular contrast agent in optical imaging systems. In this work, the interaction of light and microbubbles in a turbid medium (intralipid) was investigated, particularly, the effect of MBs on the reduced scattering and absorption coefficients. Diffuse reflectance (DR) and total transmittance (TT) measurements of highly scattering intralipid suspension (0.5–5%) were measured using spectroscopic integrating sphere system in the absence and presence of Definity microbubbles. The optical properties were computed using the inverse adding doubling (IAD) software. The presence of microbubbles increased DR and decreased TT of intralipid phantoms. In the presence of MBs (0.5% volume concentration), the reflectance of the intralipid phantom increased from 35% to 100%. The reduced scattering coefficient increased significantly (30%) indicating potential use of MBs as optical contrast agents in light based modalities.http://dx.doi.org/10.1155/2014/471764 |
| spellingShingle | Homa Assadi Raffi Karshafian Alexandre Douplik Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles International Journal of Photoenergy |
| title | Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles |
| title_full | Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles |
| title_fullStr | Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles |
| title_full_unstemmed | Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles |
| title_short | Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles |
| title_sort | optical scattering properties of intralipid phantom in presence of encapsulated microbubbles |
| url | http://dx.doi.org/10.1155/2014/471764 |
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