The obstetrical management of HIV-positive pregnancy
The human immunodeficiency virus (HIV) infection is a real public health problem in both developing and developed countries. HIV infection has not been treated efficiently for a long time, with HIV-positive women at increased risk of transmitting the infection to their newborns. Without the appropri...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Journal of Mind and Medical Sciences |
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| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1331&context=jmms |
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| author | Mihai George Loghin Petre Gabriel Gorescki Romina Marina Sima Liana Pleș Daniela Gabriela Balan Ioana Paunica Oana Denisa Bălălău |
| author_facet | Mihai George Loghin Petre Gabriel Gorescki Romina Marina Sima Liana Pleș Daniela Gabriela Balan Ioana Paunica Oana Denisa Bălălău |
| author_sort | Mihai George Loghin |
| collection | DOAJ |
| description | The human immunodeficiency virus (HIV) infection is a real public health problem in both developing and developed countries. HIV infection has not been treated efficiently for a long time, with HIV-positive women at increased risk of transmitting the infection to their newborns. Without the appropriate treatment, the evolution of the infection is relatively fast. Due to the antiretroviral treatment, the progression of the disease is blocked during the period of asymptomatic infection, and the risk of neonatal transmission is very low. HIV-positive patients undergoing antiretroviral therapy develop undetectable viremia and, in such situations, patients no longer have a risk of transmitting the infection. The antiretroviral medication is a combination of several classes of drugs (protease inhibitors, nucleoside and non-nucleoside reverse transcriptase inhibitors, integrase inhibitors and CCR5 inhibitors) whose aim is to stop the viral replication at different stages. The infection is most often transmitted in the perinatal period, so it is very important that we know the maternal viremia and choose the type of birth with the lowest risk of transmitting the infection to the fetus. For this reason, any HIV-positive patient with detectable viremia at childbirth should receive treatment during labor and delivery, with a nucleoside or non-nucleoside reverse transcriptase inhibitor that crosses the fetal-placental barrier. |
| format | Article |
| id | doaj-art-765b3f0e08884c77a5152c2ae1d30719 |
| institution | DOAJ |
| issn | 2392-7674 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-765b3f0e08884c77a5152c2ae1d307192025-08-20T03:09:52ZengMDPI AGJournal of Mind and Medical Sciences2392-76742022-04-019111111710.22543/7674.91.P111117The obstetrical management of HIV-positive pregnancyMihai George Loghin0Petre Gabriel Gorescki1Romina Marina Sima2Liana Pleș3Daniela Gabriela Balan4Ioana Paunica5Oana Denisa Bălălău6CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIAST. IOAN EMERGENCY UNIVERSITY HOSPITAL, BUCUR MATERNITY, BUCHAREST, ROMANIACAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIACAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIACAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF PHYSIOLOGY, BUCHAREST, ROMANIACAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIACAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIAThe human immunodeficiency virus (HIV) infection is a real public health problem in both developing and developed countries. HIV infection has not been treated efficiently for a long time, with HIV-positive women at increased risk of transmitting the infection to their newborns. Without the appropriate treatment, the evolution of the infection is relatively fast. Due to the antiretroviral treatment, the progression of the disease is blocked during the period of asymptomatic infection, and the risk of neonatal transmission is very low. HIV-positive patients undergoing antiretroviral therapy develop undetectable viremia and, in such situations, patients no longer have a risk of transmitting the infection. The antiretroviral medication is a combination of several classes of drugs (protease inhibitors, nucleoside and non-nucleoside reverse transcriptase inhibitors, integrase inhibitors and CCR5 inhibitors) whose aim is to stop the viral replication at different stages. The infection is most often transmitted in the perinatal period, so it is very important that we know the maternal viremia and choose the type of birth with the lowest risk of transmitting the infection to the fetus. For this reason, any HIV-positive patient with detectable viremia at childbirth should receive treatment during labor and delivery, with a nucleoside or non-nucleoside reverse transcriptase inhibitor that crosses the fetal-placental barrier. https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1331&context=jmmshivantiretroviral therapychildbirthpregnancyobstetrical managementcd4 t-lymphocytes |
| spellingShingle | Mihai George Loghin Petre Gabriel Gorescki Romina Marina Sima Liana Pleș Daniela Gabriela Balan Ioana Paunica Oana Denisa Bălălău The obstetrical management of HIV-positive pregnancy Journal of Mind and Medical Sciences hiv antiretroviral therapy childbirth pregnancy obstetrical management cd4 t-lymphocytes |
| title | The obstetrical management of HIV-positive pregnancy |
| title_full | The obstetrical management of HIV-positive pregnancy |
| title_fullStr | The obstetrical management of HIV-positive pregnancy |
| title_full_unstemmed | The obstetrical management of HIV-positive pregnancy |
| title_short | The obstetrical management of HIV-positive pregnancy |
| title_sort | obstetrical management of hiv positive pregnancy |
| topic | hiv antiretroviral therapy childbirth pregnancy obstetrical management cd4 t-lymphocytes |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1331&context=jmms |
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