Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation

Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation

Abstract Mammalian chromosomes fold into arrays of megabase‐sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA. TADs have internal substructures that are often cell type specific, but their higher‐order organization remains...

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Bibliographic Details
Main Authors: James Fraser, Carmelo Ferrai, Andrea M Chiariello, Markus Schueler, Tiago Rito, Giovanni Laudanno, Mariano Barbieri, Benjamin L Moore, Dorothee CA Kraemer, Stuart Aitken, Sheila Q Xie, Kelly J Morris, Masayoshi Itoh, Hideya Kawaji, Ines Jaeger, Yoshihide Hayashizaki, Piero Carninci, Alistair RR Forrest, The FANTOM Consortium, Colin A Semple, Josée Dostie, Ana Pombo, Mario Nicodemi
Format: Article
Language:English
Published: Springer Nature 2015-12-01
Series:Molecular Systems Biology
Subjects:
chromatin contacts
chromosome architecture
epigenetics
gene expression
polymer modelling
Online Access:https://doi.org/10.15252/msb.20156492
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