The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals
Abstract Background Recent research has highlighted the role of fronto-parietal brain networks and cognitive control in mood disorders. Transcranial direct current stimulation (tDCS) and computer-based cognitive training are used in post-stroke rehabilitation. This study examined the combined effect...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12883-025-04042-6 |
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| author | Csaba Kazinczi Noemi Szepfalusi Viola Luca Nemeth Adrienn Holczer Katalin Jakab Laszlo Vecsei Peter Klivenyi Anita Must Mihaly Racsmany |
| author_facet | Csaba Kazinczi Noemi Szepfalusi Viola Luca Nemeth Adrienn Holczer Katalin Jakab Laszlo Vecsei Peter Klivenyi Anita Must Mihaly Racsmany |
| author_sort | Csaba Kazinczi |
| collection | DOAJ |
| description | Abstract Background Recent research has highlighted the role of fronto-parietal brain networks and cognitive control in mood disorders. Transcranial direct current stimulation (tDCS) and computer-based cognitive training are used in post-stroke rehabilitation. This study examined the combined effects ofof computer-based inhibitory control training (ICCT) and anodal tDCS on post-stroke depression and anxiety. Methods Thirty-five participants were randomly assigned to one of three groups: active tDCS treatment (A), sham tDCS treatment with ICCT (T), or active tDCS with ICCT (AT), for a duration of ten days. Primary outcome measures included the Beck Depression Inventory (BDI), Hamilton Depression Rating Scale (HAM-D), and Spielberger’s State-Trait Anxiety Inventory (STAI-S/T). Statistical analysis was performed using a Mixed-model Analysis of Variance, with supplementary Bayesian analysis. Results The AT group showed a significant improvement in BDI scores (p < .001), whereas no significant effects were observed on the HAM-D, STAI-T, or STAI-S scales. Conclusions The combination of tDCS and ICCT reduced depressive symptoms as measured by the BDI; while no significant effects were found with either treatment alone. Further research is needed to explore the mechanisms behind the synergistic effects in the treatment of post-stroke mood disorders. |
| format | Article |
| id | doaj-art-7653a1a72dfe47f89797e514a941ce74 |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Neurology |
| spelling | doaj-art-7653a1a72dfe47f89797e514a941ce742025-02-02T12:30:11ZengBMCBMC Neurology1471-23772025-01-0125111610.1186/s12883-025-04042-6The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individualsCsaba Kazinczi0Noemi Szepfalusi1Viola Luca Nemeth2Adrienn Holczer3Katalin Jakab4Laszlo Vecsei5Peter Klivenyi6Anita Must7Mihaly Racsmany8Department of Neurology, University of SzegedDepartment of Neurology, University of SzegedDepartment of Neurology, University of SzegedDepartment of Neurology, University of SzegedDepartment of Neurology, University of SzegedDepartment of Neurology, University of SzegedDepartment of Neurology, University of SzegedDepartment of Psychiatry, Whanganui District Health BoardUniversity of Szeged, Institute of PsychologyAbstract Background Recent research has highlighted the role of fronto-parietal brain networks and cognitive control in mood disorders. Transcranial direct current stimulation (tDCS) and computer-based cognitive training are used in post-stroke rehabilitation. This study examined the combined effects ofof computer-based inhibitory control training (ICCT) and anodal tDCS on post-stroke depression and anxiety. Methods Thirty-five participants were randomly assigned to one of three groups: active tDCS treatment (A), sham tDCS treatment with ICCT (T), or active tDCS with ICCT (AT), for a duration of ten days. Primary outcome measures included the Beck Depression Inventory (BDI), Hamilton Depression Rating Scale (HAM-D), and Spielberger’s State-Trait Anxiety Inventory (STAI-S/T). Statistical analysis was performed using a Mixed-model Analysis of Variance, with supplementary Bayesian analysis. Results The AT group showed a significant improvement in BDI scores (p < .001), whereas no significant effects were observed on the HAM-D, STAI-T, or STAI-S scales. Conclusions The combination of tDCS and ICCT reduced depressive symptoms as measured by the BDI; while no significant effects were found with either treatment alone. Further research is needed to explore the mechanisms behind the synergistic effects in the treatment of post-stroke mood disorders.https://doi.org/10.1186/s12883-025-04042-6TDCSComputer-based cognitive trainingDepressionAnxiety |
| spellingShingle | Csaba Kazinczi Noemi Szepfalusi Viola Luca Nemeth Adrienn Holczer Katalin Jakab Laszlo Vecsei Peter Klivenyi Anita Must Mihaly Racsmany The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals BMC Neurology TDCS Computer-based cognitive training Depression Anxiety |
| title | The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals |
| title_full | The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals |
| title_fullStr | The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals |
| title_full_unstemmed | The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals |
| title_short | The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals |
| title_sort | effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post stroke individuals |
| topic | TDCS Computer-based cognitive training Depression Anxiety |
| url | https://doi.org/10.1186/s12883-025-04042-6 |
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