Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study
Introduction: A promising technique to treat persistent olfactory impairment has recently been explored: platelet rich plasma (PRP) injection into the olfactory mucosa. Objectives: This study aimed to determine efficacy, safety, and feasibility of a new PRP injection protocol in treating persiste...
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| Format: | Article |
| Language: | English |
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Portuguese Society of Otolaryngology and Head and Neck Surgery
2023-12-01
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| Series: | Revista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço |
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| Online Access: | https://journalsporl.com/index.php/sporl/article/view/2048 |
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| _version_ | 1849684407013605376 |
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| author | Francisco Alves de Sousa André de Sousa Machado Joana Raquel Costa João Tavares Correia Afonso Castro Ana Nóbrega Pinto Ana Silva Mariline Santos Luís Meireles |
| author_facet | Francisco Alves de Sousa André de Sousa Machado Joana Raquel Costa João Tavares Correia Afonso Castro Ana Nóbrega Pinto Ana Silva Mariline Santos Luís Meireles |
| author_sort | Francisco Alves de Sousa |
| collection | DOAJ |
| description |
Introduction: A promising technique to treat persistent olfactory impairment has recently been explored: platelet rich plasma (PRP) injection into the olfactory mucosa.
Objectives: This study aimed to determine efficacy, safety, and feasibility of a new PRP injection protocol in treating persistent COVID-19 induced olfactory dysfunction (pCIOD).
Material and Methods: Patients with pCIOD lasting for ≥ 12 months were enrolled. All patients had previously performed olfactory training and adjuvant therapy without achieving substantial improvement. Olfactory perception threshold (OPT) and visual analog scale (VAS) were measured at baseline, one month and three months after injection.
Results: Twenty patients were enrolled. There was a significant change in OPT after injection (mean baseline OPT: 4.36 ± 1.6 versus 1-month after injection: 6.9 ± 2.6, p = 0.012 versus 3-months after injection: 7.2 ± 2.8, p =0.009). No severe complications were reported.
Conclusions: Single-site PRP injection into the olfactory mucosa is a novel, safe and effective approach that may enhance olfactory recovery in pCIOD patients.
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| format | Article |
| id | doaj-art-764f8203afc14d4dbb03bb9bb93c7622 |
| institution | DOAJ |
| issn | 2184-6499 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Portuguese Society of Otolaryngology and Head and Neck Surgery |
| record_format | Article |
| series | Revista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço |
| spelling | doaj-art-764f8203afc14d4dbb03bb9bb93c76222025-08-20T03:23:27ZengPortuguese Society of Otolaryngology and Head and Neck SurgeryRevista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço2184-64992023-12-0161410.34631/sporl.2048Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective studyFrancisco Alves de Sousa0André de Sousa Machado1Joana Raquel Costa2João Tavares Correia3Afonso Castro4Ana Nóbrega Pinto5Ana Silva6Mariline Santos7Luís Meireles8Centro Hospitalar Universitário de Santo António Porto, PortugalCentro Hospitalar Universitário de Santo António Porto, PortugalCentro Hospitalar Universitário de Santo António Porto, PortugalCentro Hospitalar Universitário de Santo António Porto, PortugalCentro Hospitalar Universitário de Santo António Porto, PortugalCentro Hospitalar Universitário de Santo António Porto, PortugalCentro Hospitalar Universitário de Santo António Porto, PortugalCentro Hospitalar Universitário de Santo António Porto, PortugalCentro Hospitalar Universitário de Santo António Porto, Portugal Introduction: A promising technique to treat persistent olfactory impairment has recently been explored: platelet rich plasma (PRP) injection into the olfactory mucosa. Objectives: This study aimed to determine efficacy, safety, and feasibility of a new PRP injection protocol in treating persistent COVID-19 induced olfactory dysfunction (pCIOD). Material and Methods: Patients with pCIOD lasting for ≥ 12 months were enrolled. All patients had previously performed olfactory training and adjuvant therapy without achieving substantial improvement. Olfactory perception threshold (OPT) and visual analog scale (VAS) were measured at baseline, one month and three months after injection. Results: Twenty patients were enrolled. There was a significant change in OPT after injection (mean baseline OPT: 4.36 ± 1.6 versus 1-month after injection: 6.9 ± 2.6, p = 0.012 versus 3-months after injection: 7.2 ± 2.8, p =0.009). No severe complications were reported. Conclusions: Single-site PRP injection into the olfactory mucosa is a novel, safe and effective approach that may enhance olfactory recovery in pCIOD patients. https://journalsporl.com/index.php/sporl/article/view/2048COVID-19olfactory dysfunctionanosmiahyposmiaplatelet rich plasmasingle-site |
| spellingShingle | Francisco Alves de Sousa André de Sousa Machado Joana Raquel Costa João Tavares Correia Afonso Castro Ana Nóbrega Pinto Ana Silva Mariline Santos Luís Meireles Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study Revista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço COVID-19 olfactory dysfunction anosmia hyposmia platelet rich plasma single-site |
| title | Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
| title_full | Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
| title_fullStr | Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
| title_full_unstemmed | Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
| title_short | Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
| title_sort | use of platelet rich plasma in persistent olfactory dysfunction after covid 19 a prospective study |
| topic | COVID-19 olfactory dysfunction anosmia hyposmia platelet rich plasma single-site |
| url | https://journalsporl.com/index.php/sporl/article/view/2048 |
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