LncRNA small nucleolar RNA host gene 1 (SNHG1) mediates acidic bile salt-induced EMT via the ULK1-Notch1 axis in Barrett’s esophagus

LncRNA small nucleolar RNA host gene 1 (SNHG1) mediates acidic bile salt-induced EMT via the ULK1-Notch1 axis in Barrett’s esophagus

Abstract Barrett’s esophagus (BE) is a precancerous condition closely linked to chronic gastroesophageal reflux disease, characterized by the abnormal transformation of esophageal squamous mucosa into specialized intestinal-type epithelium, significantly elevating the risk of esophageal adenocarcino...

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Bibliographic Details
Main Authors: Jianfeng Zhou, Rongyan Zhao, Zixiang Li, Xuelan Ma, Wenke Jin, Yong Yuan, Ning Li, Bo Liu, Yushang Yang
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Molecular Biomedicine
Subjects:
Barrett’s esophagus
Small nucleolar RNA host gene 1 (SNHG1)
UNC-52-like kinase 1 (ULK1)
Notch1
Epithelial-mesenchymal transition (EMT)
Online Access:https://doi.org/10.1186/s43556-025-00285-4
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