Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase.

Large multinucleated Reed-Sternberg cells (RS) and large mononucleated Hodgkin cells (H) are traditionally considered to be the neoplastic population in classical Hodgkin lymphoma, (cHL) and postulated to promote the disease. However, the contribution of these larger cells to the progression of cHL...

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Bibliographic Details
Main Authors: Ana Xavier de Carvalho, Helder Maiato, André F Maia, Susana A Ribeiro, Patrícia Pontes, Wendy Bickmore, William C Earnshaw, Clara Sambade
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0124629
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