Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion
Exposure to specific alkali and alkaline earth elements(AEs/AEEs) has been reported that are linked to an increased risk of spontaneous abortion. However, the direct evidence of exposure in the uterus are absent. Therefore, we collected chorionic villi after spontaneous abortion or induced abortion...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015926 |
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| author | Meng Lin Yutong Wang Xiaoye Wang Lailai Yan Linlin Wang Chan Tian |
| author_facet | Meng Lin Yutong Wang Xiaoye Wang Lailai Yan Linlin Wang Chan Tian |
| author_sort | Meng Lin |
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| description | Exposure to specific alkali and alkaline earth elements(AEs/AEEs) has been reported that are linked to an increased risk of spontaneous abortion. However, the direct evidence of exposure in the uterus are absent. Therefore, we collected chorionic villi after spontaneous abortion or induced abortion in Peking University Third Hospital. The concentrations of six alkali and alkaline earth elements in chorionic villi were measured using inductively coupled plasma mass spectrometry (ICP-MS). Through using logistic regression, Bayesian kernel machine regression (BKMR) and Weighted quantile sum regression (WQS) model, we assessed single and mixed exposure effects of alkali and alkaline earth elements on spontaneous abortion. In terms of the individual effect, high concentration group of barium (Ba) increased the risk of spontaneous abortion by 150 % (95 % CI: 1.38–4.51), whereas rubidium (Rb), cesium (Cs) and Magnesium (Mg) all clearly demonstrated dose dependency in reducing the incidence of spontaneous abortion. The BKMR model demonstrated that as the mixed exposure percentile increased, the likelihood of spontaneous abortion decreased almost linearly. For every quartile increasing in the WQS index, the risk of spontaneous abortion decreased (OR: 0.21, 95 % CI: 0.13–0.33), with Mg and Rb having the highest weights at 0.587 and 0.367, respectively. According to our findings, there were negative dose-response relationships between Mg and Rb levels and risk for spontaneous abortion, but exposure to higher concentration of Ba in the chorionic villi was positively associated with the risk of it. |
| format | Article |
| id | doaj-art-7640660e1c3d4164b5462e9e59f87201 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-7640660e1c3d4164b5462e9e59f872012025-02-12T05:29:25ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117516Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortionMeng Lin0Yutong Wang1Xiaoye Wang2Lailai Yan3Linlin Wang4Chan Tian5Department of Medical Genetics, Center for Medical Genetics, Peking University, Beijing 100191, China; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Center for Medical Genetics, Peking University, Beijing 100191, China; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing 100191, China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, ChinaDepartment of Medical Genetics, Center for Medical Genetics, Peking University, Beijing 100191, China; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Center for Medical Genetics, Peking University, Beijing 100191, China; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing 100191, China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, ChinaDepartment of Medical Genetics, Center for Medical Genetics, Peking University, Beijing 100191, China; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Center for Medical Genetics, Peking University, Beijing 100191, ChinaDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing 100191, ChinaInstitute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Corresponding author.Department of Medical Genetics, Center for Medical Genetics, Peking University, Beijing 100191, China; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Center for Medical Genetics, Peking University, Beijing 100191, China; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing 100191, China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China; Correspondence to: 38 College Road, Haidian District, Beijing 100191, China.Exposure to specific alkali and alkaline earth elements(AEs/AEEs) has been reported that are linked to an increased risk of spontaneous abortion. However, the direct evidence of exposure in the uterus are absent. Therefore, we collected chorionic villi after spontaneous abortion or induced abortion in Peking University Third Hospital. The concentrations of six alkali and alkaline earth elements in chorionic villi were measured using inductively coupled plasma mass spectrometry (ICP-MS). Through using logistic regression, Bayesian kernel machine regression (BKMR) and Weighted quantile sum regression (WQS) model, we assessed single and mixed exposure effects of alkali and alkaline earth elements on spontaneous abortion. In terms of the individual effect, high concentration group of barium (Ba) increased the risk of spontaneous abortion by 150 % (95 % CI: 1.38–4.51), whereas rubidium (Rb), cesium (Cs) and Magnesium (Mg) all clearly demonstrated dose dependency in reducing the incidence of spontaneous abortion. The BKMR model demonstrated that as the mixed exposure percentile increased, the likelihood of spontaneous abortion decreased almost linearly. For every quartile increasing in the WQS index, the risk of spontaneous abortion decreased (OR: 0.21, 95 % CI: 0.13–0.33), with Mg and Rb having the highest weights at 0.587 and 0.367, respectively. According to our findings, there were negative dose-response relationships between Mg and Rb levels and risk for spontaneous abortion, but exposure to higher concentration of Ba in the chorionic villi was positively associated with the risk of it.http://www.sciencedirect.com/science/article/pii/S0147651324015926Alkali and alkaline earth elementsSpontaneous abortionChorionic villusBayesian kernel machine regressionWeighted quantile sum regression |
| spellingShingle | Meng Lin Yutong Wang Xiaoye Wang Lailai Yan Linlin Wang Chan Tian Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion Ecotoxicology and Environmental Safety Alkali and alkaline earth elements Spontaneous abortion Chorionic villus Bayesian kernel machine regression Weighted quantile sum regression |
| title | Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion |
| title_full | Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion |
| title_fullStr | Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion |
| title_full_unstemmed | Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion |
| title_short | Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion |
| title_sort | association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion |
| topic | Alkali and alkaline earth elements Spontaneous abortion Chorionic villus Bayesian kernel machine regression Weighted quantile sum regression |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015926 |
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