Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D1-like receptor signaling
Abstract Physical exercise has lasting positive influence on mental health. However, its cellular substrate remains to be elucidated. Recently, dopamine D1-like receptor activation induced by noradrenaline has been suggested to underlie exercise-dependent augmentation of antidepressant effects. The...
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BMC
2025-06-01
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| Series: | Molecular Brain |
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| Online Access: | https://doi.org/10.1186/s13041-025-01219-5 |
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| author | Katsunori Kobayashi |
| author_facet | Katsunori Kobayashi |
| author_sort | Katsunori Kobayashi |
| collection | DOAJ |
| description | Abstract Physical exercise has lasting positive influence on mental health. However, its cellular substrate remains to be elucidated. Recently, dopamine D1-like receptor activation induced by noradrenaline has been suggested to underlie exercise-dependent augmentation of antidepressant effects. The present study demonstrates that exercise induces a long-term enhancement of this atypical catecholaminergic signaling. Noradrenaline potentiates hippocampal mossy fiber synaptic transmission by activating D1-like receptors in mice. Voluntary exercise by wheel running enhanced this noradrenaline-D1-like receptor signaling within 5 days. The enhancement of the noradrenaline-D1-like receptor signaling did not require the integrity of noradrenergic fibers and was maintained for more than 2 weeks after cessation of wheel running. Notably, the effect of exercise was more robustly seen in D1-like receptor signaling activated by noradrenaline as compared with dopamine, indicating particular responsiveness of the noradrenaline-activated D1-like receptor signaling to exercise. These results suggest that exercise could exert lasting influence on brain functioning via plasticity of the hippocampal noradrenaline-D1-like receptor signaling. |
| format | Article |
| id | doaj-art-76293ba100c94ad39fe2f6271eb4ed95 |
| institution | OA Journals |
| issn | 1756-6606 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj-art-76293ba100c94ad39fe2f6271eb4ed952025-08-20T02:37:36ZengBMCMolecular Brain1756-66062025-06-011811410.1186/s13041-025-01219-5Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D1-like receptor signalingKatsunori Kobayashi0Department of System Neurophysiology, Wakayama Medical UniversityAbstract Physical exercise has lasting positive influence on mental health. However, its cellular substrate remains to be elucidated. Recently, dopamine D1-like receptor activation induced by noradrenaline has been suggested to underlie exercise-dependent augmentation of antidepressant effects. The present study demonstrates that exercise induces a long-term enhancement of this atypical catecholaminergic signaling. Noradrenaline potentiates hippocampal mossy fiber synaptic transmission by activating D1-like receptors in mice. Voluntary exercise by wheel running enhanced this noradrenaline-D1-like receptor signaling within 5 days. The enhancement of the noradrenaline-D1-like receptor signaling did not require the integrity of noradrenergic fibers and was maintained for more than 2 weeks after cessation of wheel running. Notably, the effect of exercise was more robustly seen in D1-like receptor signaling activated by noradrenaline as compared with dopamine, indicating particular responsiveness of the noradrenaline-activated D1-like receptor signaling to exercise. These results suggest that exercise could exert lasting influence on brain functioning via plasticity of the hippocampal noradrenaline-D1-like receptor signaling.https://doi.org/10.1186/s13041-025-01219-5ExerciseNoradrenalineDopamineHippocampusMossy fiber |
| spellingShingle | Katsunori Kobayashi Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D1-like receptor signaling Molecular Brain Exercise Noradrenaline Dopamine Hippocampus Mossy fiber |
| title | Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D1-like receptor signaling |
| title_full | Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D1-like receptor signaling |
| title_fullStr | Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D1-like receptor signaling |
| title_full_unstemmed | Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D1-like receptor signaling |
| title_short | Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D1-like receptor signaling |
| title_sort | chronic voluntary exercise induces plasticity of noradrenaline activated dopamine d1 like receptor signaling |
| topic | Exercise Noradrenaline Dopamine Hippocampus Mossy fiber |
| url | https://doi.org/10.1186/s13041-025-01219-5 |
| work_keys_str_mv | AT katsunorikobayashi chronicvoluntaryexerciseinducesplasticityofnoradrenalineactivateddopamined1likereceptorsignaling |