Carbon-Infiltrated Carbon Nanotube Topography Reduces the Growth of <i>Staphylococcus aureus</i> Biofilms
Orthopedic implant-associated infections are a growing problem. These infections are often associated with bacterial biofilms, such as those formed by <i>Staphylococcus aureus</i>. Nanotextured surfaces can reduce or prevent the development of bacterial biofilms and could help reduce inf...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/15/7/510 |
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| author | Lucy C. Bowden Sidney T. Sithole Anton E. Bowden Brian D. Jensen Bradford K. Berges |
| author_facet | Lucy C. Bowden Sidney T. Sithole Anton E. Bowden Brian D. Jensen Bradford K. Berges |
| author_sort | Lucy C. Bowden |
| collection | DOAJ |
| description | Orthopedic implant-associated infections are a growing problem. These infections are often associated with bacterial biofilms, such as those formed by <i>Staphylococcus aureus</i>. Nanotextured surfaces can reduce or prevent the development of bacterial biofilms and could help reduce infection rates and severity. Previous work has shown that a carbon-infiltrated carbon nanotube (CICNT) surface reduces the growth of <i>S. aureus</i> biofilms. This work expands on previous experiments, showing that the topography of the CICNT, rather than its surface chemistry, is responsible for the reduction in biofilm growth. Additionally, the CICNT surface does not reduce biofilm growth by killing the bacteria or by preventing their attachment. Rather it likely slows cell growth, resulting in fewer cells and reduced biofilm formation. |
| format | Article |
| id | doaj-art-7621b4f7b86747ff8003fab653d00a45 |
| institution | DOAJ |
| issn | 2079-4991 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-7621b4f7b86747ff8003fab653d00a452025-08-20T03:03:21ZengMDPI AGNanomaterials2079-49912025-03-0115751010.3390/nano15070510Carbon-Infiltrated Carbon Nanotube Topography Reduces the Growth of <i>Staphylococcus aureus</i> BiofilmsLucy C. Bowden0Sidney T. Sithole1Anton E. Bowden2Brian D. Jensen3Bradford K. Berges4Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USADepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USADepartment of Mechanical Engineering, Brigham Young University, Provo, UT 84602, USADepartment of Mechanical Engineering, Brigham Young University, Provo, UT 84602, USADepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USAOrthopedic implant-associated infections are a growing problem. These infections are often associated with bacterial biofilms, such as those formed by <i>Staphylococcus aureus</i>. Nanotextured surfaces can reduce or prevent the development of bacterial biofilms and could help reduce infection rates and severity. Previous work has shown that a carbon-infiltrated carbon nanotube (CICNT) surface reduces the growth of <i>S. aureus</i> biofilms. This work expands on previous experiments, showing that the topography of the CICNT, rather than its surface chemistry, is responsible for the reduction in biofilm growth. Additionally, the CICNT surface does not reduce biofilm growth by killing the bacteria or by preventing their attachment. Rather it likely slows cell growth, resulting in fewer cells and reduced biofilm formation.https://www.mdpi.com/2079-4991/15/7/510biofilmcarbon nanotubesMRSA<i>Staphylococcus aureus</i>nanostructured surface |
| spellingShingle | Lucy C. Bowden Sidney T. Sithole Anton E. Bowden Brian D. Jensen Bradford K. Berges Carbon-Infiltrated Carbon Nanotube Topography Reduces the Growth of <i>Staphylococcus aureus</i> Biofilms Nanomaterials biofilm carbon nanotubes MRSA <i>Staphylococcus aureus</i> nanostructured surface |
| title | Carbon-Infiltrated Carbon Nanotube Topography Reduces the Growth of <i>Staphylococcus aureus</i> Biofilms |
| title_full | Carbon-Infiltrated Carbon Nanotube Topography Reduces the Growth of <i>Staphylococcus aureus</i> Biofilms |
| title_fullStr | Carbon-Infiltrated Carbon Nanotube Topography Reduces the Growth of <i>Staphylococcus aureus</i> Biofilms |
| title_full_unstemmed | Carbon-Infiltrated Carbon Nanotube Topography Reduces the Growth of <i>Staphylococcus aureus</i> Biofilms |
| title_short | Carbon-Infiltrated Carbon Nanotube Topography Reduces the Growth of <i>Staphylococcus aureus</i> Biofilms |
| title_sort | carbon infiltrated carbon nanotube topography reduces the growth of i staphylococcus aureus i biofilms |
| topic | biofilm carbon nanotubes MRSA <i>Staphylococcus aureus</i> nanostructured surface |
| url | https://www.mdpi.com/2079-4991/15/7/510 |
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