Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis
Objective: This study aimed to find new serum biochemistry parameters, especially for the early identification of severe AP. In the study serum cytokine levels (TNF-A, IL-1, IL-6, IL-10, IL-21), biochemical parameters (Aquaporin-1, Hepcidine, Iron, Zinc, Copper, Nitric Oxide, C-Reactive protein), an...
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Selcuk University Press
2024-04-01
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| Series: | Genel Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/3008290 |
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| author | Hamza Erdoğdu Mehmet Bayraktar Ahmet Uyanıkoğlu Oruç Aslan Nihayet Bayraktar Ali Öztürk |
| author_facet | Hamza Erdoğdu Mehmet Bayraktar Ahmet Uyanıkoğlu Oruç Aslan Nihayet Bayraktar Ali Öztürk |
| author_sort | Hamza Erdoğdu |
| collection | DOAJ |
| description | Objective: This study aimed to find new serum biochemistry parameters, especially for the early identification of severe AP. In the study serum cytokine levels (TNF-A, IL-1, IL-6, IL-10, IL-21), biochemical parameters (Aquaporin-1, Hepcidine, Iron, Zinc, Copper, Nitric Oxide, C-Reactive protein), and oxidative stress parameters analysis were performed.
Method: A total of 46 patients with AP and 46 healthy controls were included in this study. Serum cytokine levels, biochemical, and oxidative stress parameters by the ELISA method, and CRP by the immunoturbidimetric method were measured.
Results: When patients with AP and control groups were compared, all studied parameters were found to be statistically significant (p<0.05). However, IL-1 was found to be insignificant (p>0.05). Therefore, the Mann-Whitney U test, which is a non-parametric test, was found suitable to determine whether there was a significant difference between the patient and control groups.
Conclusions: Investigating the role of cytokines, oxidative stress and other biochemical parameters in the pathogenesis and course of the disease may contribute to a better understanding of the disease process and its therapeutic value. It showed a significant increase in oxidative stress parameters and biochemical parameters such as aquaporin-1, hepcidin, lipase, and amylase, which may help in the diagnosis of AP. |
| format | Article |
| id | doaj-art-76203524fd38409baae397bff32195cc |
| institution | Kabale University |
| issn | 2602-3741 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj-art-76203524fd38409baae397bff32195cc2025-01-03T01:05:26ZengSelcuk University PressGenel Tıp Dergisi2602-37412024-04-0134215816510.54005/geneltip.1264527154Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute PancreatitisHamza Erdoğdu0Mehmet Bayraktar1Ahmet Uyanıkoğlu2Oruç Aslan3Nihayet Bayraktar4Ali Öztürk5HARRAN ÜNİVERSİTESİHARRAN ÜNİVERSİTESİHARRAN ÜNİVERSİTESİHARRAN ÜNİVERSİTESİHARRAN ÜNİVERSİTESİNİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜObjective: This study aimed to find new serum biochemistry parameters, especially for the early identification of severe AP. In the study serum cytokine levels (TNF-A, IL-1, IL-6, IL-10, IL-21), biochemical parameters (Aquaporin-1, Hepcidine, Iron, Zinc, Copper, Nitric Oxide, C-Reactive protein), and oxidative stress parameters analysis were performed. Method: A total of 46 patients with AP and 46 healthy controls were included in this study. Serum cytokine levels, biochemical, and oxidative stress parameters by the ELISA method, and CRP by the immunoturbidimetric method were measured. Results: When patients with AP and control groups were compared, all studied parameters were found to be statistically significant (p<0.05). However, IL-1 was found to be insignificant (p>0.05). Therefore, the Mann-Whitney U test, which is a non-parametric test, was found suitable to determine whether there was a significant difference between the patient and control groups. Conclusions: Investigating the role of cytokines, oxidative stress and other biochemical parameters in the pathogenesis and course of the disease may contribute to a better understanding of the disease process and its therapeutic value. It showed a significant increase in oxidative stress parameters and biochemical parameters such as aquaporin-1, hepcidin, lipase, and amylase, which may help in the diagnosis of AP.https://dergipark.org.tr/tr/download/article-file/3008290acute pancreatitiscytokineoxidative stresssome other biochemical parametersakut pankreatitsitokinoksidatif stresdiğer bazı biyokimyasal parametreler |
| spellingShingle | Hamza Erdoğdu Mehmet Bayraktar Ahmet Uyanıkoğlu Oruç Aslan Nihayet Bayraktar Ali Öztürk Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis Genel Tıp Dergisi acute pancreatitis cytokine oxidative stress some other biochemical parameters akut pankreatit sitokin oksidatif stres diğer bazı biyokimyasal parametreler |
| title | Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis |
| title_full | Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis |
| title_fullStr | Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis |
| title_full_unstemmed | Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis |
| title_short | Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis |
| title_sort | investigation of cytokines biochemical parameters and oxidative stress levels in serum of patients with acute pancreatitis |
| topic | acute pancreatitis cytokine oxidative stress some other biochemical parameters akut pankreatit sitokin oksidatif stres diğer bazı biyokimyasal parametreler |
| url | https://dergipark.org.tr/tr/download/article-file/3008290 |
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