Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population: a meta-analysis and systematic review of randomized controlled trials
Aims: This meta-analysis and systematic review aimed to comprehensively investigate the effects of vitamin K supplementation on bone mineral density (BMD) at various sites and bone metabolism in middle-aged and older adults. Methods: The databases of PubMed, Web of Science, and Cochrane Library we...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The British Editorial Society of Bone & Joint Surgery
2024-12-01
|
| Series: | Bone & Joint Research |
| Subjects: | |
| Online Access: | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1312.BJR-2024-0053.R1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583722095869952 |
|---|---|
| author | Chenqi Xie Jianbao Gong Chenglong Zheng Junwei Zhang Jie Gao Chunyan Tian Xiaofei Guo Shiyou Dai Tianlin Gao |
| author_facet | Chenqi Xie Jianbao Gong Chenglong Zheng Junwei Zhang Jie Gao Chunyan Tian Xiaofei Guo Shiyou Dai Tianlin Gao |
| author_sort | Chenqi Xie |
| collection | DOAJ |
| description | Aims: This meta-analysis and systematic review aimed to comprehensively investigate the effects of vitamin K supplementation on bone mineral density (BMD) at various sites and bone metabolism in middle-aged and older adults. Methods: The databases of PubMed, Web of Science, and Cochrane Library were thoroughly searched from inception to July 2023. Results: The results revealed that vitamin K supplementation increased BMD at the lumbar spine (p = 0.035). Moreover, the pooled effects demonstrated a notable increase in carboxylated osteocalcin (cOC) (p = 0.004), a decrease in uncarboxylated osteocalcin (ucOC) (p < 0.001), and no significant effect on total osteocalcin (tOC) (p = 0.076). Accordingly, the ratio of cOC to ucOC (p = 0.002) significantly increased, while the ratio of ucOC to tOC decreased (p = 0.043). However, there was no significant effect of vitamin K supplementation on other bone metabolism markers, such as cross-linked telopeptide of type 1 collagen (NTx), bone alkaline phosphatase (BAP), and procollagen I N-terminal propeptide (PINP). Subgroup analysis revealed that vitamin K notably enhanced bone health in females by increasing lumbar spine BMD (p = 0.028) and decreasing ucOC (p < 0.001). Vitamin K, especially vitamin K2, exhibited effects on maintaining or increasing lumbar spine BMD, and influencing the balance of cOC and ucOC. Conclusion: This review suggests that the beneficial effects of vitamin K supplementation on bone health primarily involve enhancing the carboxylation of OC rather than altering the total amount of OC. Cite this article: Bone Joint Res 2024;13(12):750–763. |
| format | Article |
| id | doaj-art-761e6fa2e16d4f5f96261d7def130e0d |
| institution | Kabale University |
| issn | 2046-3758 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The British Editorial Society of Bone & Joint Surgery |
| record_format | Article |
| series | Bone & Joint Research |
| spelling | doaj-art-761e6fa2e16d4f5f96261d7def130e0d2025-01-28T06:54:06ZengThe British Editorial Society of Bone & Joint SurgeryBone & Joint Research2046-37582024-12-01131275076310.1302/2046-3758.1312.BJR-2024-0053.R1Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population: a meta-analysis and systematic review of randomized controlled trialsChenqi Xie0https://orcid.org/0009-0005-1287-6151Jianbao Gong1https://orcid.org/0009-0004-3873-8163Chenglong Zheng2Junwei Zhang3https://orcid.org/0000-0003-2680-4894Jie Gao4https://orcid.org/0000-0001-6035-4407Chunyan Tian5https://orcid.org/0009-0007-0217-8653Xiaofei Guo6https://orcid.org/0000-0003-0116-8609Shiyou Dai7Tianlin Gao8https://orcid.org/0000-0002-6831-1863Department of Osteoarthrosis, Qingdao Municipal Hospital affiliated to Qingdao University, Qingdao, ChinaDepartment of Osteoarthrosis, Qingdao Municipal Hospital affiliated to Qingdao University, Qingdao, ChinaJinan Railway Center for Disease Control and Prevention, Jinan, ChinaDepartment of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, ChinaSchool of Public Health, Qingdao University, Qingdao, ChinaSchool of Public Health, Qingdao University, Qingdao, ChinaSchool of Public Health, Qingdao University, Qingdao, ChinaDepartment of Osteoarthrosis, Qingdao Municipal Hospital affiliated to Qingdao University, Qingdao, ChinaSchool of Public Health, Qingdao University, Qingdao, ChinaAims: This meta-analysis and systematic review aimed to comprehensively investigate the effects of vitamin K supplementation on bone mineral density (BMD) at various sites and bone metabolism in middle-aged and older adults. Methods: The databases of PubMed, Web of Science, and Cochrane Library were thoroughly searched from inception to July 2023. Results: The results revealed that vitamin K supplementation increased BMD at the lumbar spine (p = 0.035). Moreover, the pooled effects demonstrated a notable increase in carboxylated osteocalcin (cOC) (p = 0.004), a decrease in uncarboxylated osteocalcin (ucOC) (p < 0.001), and no significant effect on total osteocalcin (tOC) (p = 0.076). Accordingly, the ratio of cOC to ucOC (p = 0.002) significantly increased, while the ratio of ucOC to tOC decreased (p = 0.043). However, there was no significant effect of vitamin K supplementation on other bone metabolism markers, such as cross-linked telopeptide of type 1 collagen (NTx), bone alkaline phosphatase (BAP), and procollagen I N-terminal propeptide (PINP). Subgroup analysis revealed that vitamin K notably enhanced bone health in females by increasing lumbar spine BMD (p = 0.028) and decreasing ucOC (p < 0.001). Vitamin K, especially vitamin K2, exhibited effects on maintaining or increasing lumbar spine BMD, and influencing the balance of cOC and ucOC. Conclusion: This review suggests that the beneficial effects of vitamin K supplementation on bone health primarily involve enhancing the carboxylation of OC rather than altering the total amount of OC. Cite this article: Bone Joint Res 2024;13(12):750–763.https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1312.BJR-2024-0053.R1vitamin kbone mineral densitybone metabolism markersbone metabolismbone mineral density (bmd)lumbar spinecollagenalkaline phosphataserandomized controlled trialshipsvitamins k1osteoporosisosteoarthritis (oa) |
| spellingShingle | Chenqi Xie Jianbao Gong Chenglong Zheng Junwei Zhang Jie Gao Chunyan Tian Xiaofei Guo Shiyou Dai Tianlin Gao Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population: a meta-analysis and systematic review of randomized controlled trials Bone & Joint Research vitamin k bone mineral density bone metabolism markers bone metabolism bone mineral density (bmd) lumbar spine collagen alkaline phosphatase randomized controlled trials hips vitamins k1 osteoporosis osteoarthritis (oa) |
| title | Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population: a meta-analysis and systematic review of randomized controlled trials |
| title_full | Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population: a meta-analysis and systematic review of randomized controlled trials |
| title_fullStr | Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population: a meta-analysis and systematic review of randomized controlled trials |
| title_full_unstemmed | Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population: a meta-analysis and systematic review of randomized controlled trials |
| title_short | Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population: a meta-analysis and systematic review of randomized controlled trials |
| title_sort | effects of vitamin k supplementation on bone mineral density at different sites and bone metabolism in the middle aged and elderly population a meta analysis and systematic review of randomized controlled trials |
| topic | vitamin k bone mineral density bone metabolism markers bone metabolism bone mineral density (bmd) lumbar spine collagen alkaline phosphatase randomized controlled trials hips vitamins k1 osteoporosis osteoarthritis (oa) |
| url | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1312.BJR-2024-0053.R1 |
| work_keys_str_mv | AT chenqixie effectsofvitaminksupplementationonbonemineraldensityatdifferentsitesandbonemetabolisminthemiddleagedandelderlypopulationametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT jianbaogong effectsofvitaminksupplementationonbonemineraldensityatdifferentsitesandbonemetabolisminthemiddleagedandelderlypopulationametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT chenglongzheng effectsofvitaminksupplementationonbonemineraldensityatdifferentsitesandbonemetabolisminthemiddleagedandelderlypopulationametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT junweizhang effectsofvitaminksupplementationonbonemineraldensityatdifferentsitesandbonemetabolisminthemiddleagedandelderlypopulationametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT jiegao effectsofvitaminksupplementationonbonemineraldensityatdifferentsitesandbonemetabolisminthemiddleagedandelderlypopulationametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT chunyantian effectsofvitaminksupplementationonbonemineraldensityatdifferentsitesandbonemetabolisminthemiddleagedandelderlypopulationametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT xiaofeiguo effectsofvitaminksupplementationonbonemineraldensityatdifferentsitesandbonemetabolisminthemiddleagedandelderlypopulationametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT shiyoudai effectsofvitaminksupplementationonbonemineraldensityatdifferentsitesandbonemetabolisminthemiddleagedandelderlypopulationametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT tianlingao effectsofvitaminksupplementationonbonemineraldensityatdifferentsitesandbonemetabolisminthemiddleagedandelderlypopulationametaanalysisandsystematicreviewofrandomizedcontrolledtrials |