Dopamine-Induced Nonmotor Symptoms of Parkinson's Disease
Nonmotor symptoms of Parkinson's disease (PD) may emerge secondary to the underlying pathogenesis of the disease, while others are recognized side effects of treatment. Inevitably, there is an overlap as the disease advances and patients require higher dosages and more complex medical regimens...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.4061/2011/485063 |
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| _version_ | 1850219841734049792 |
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| author | Ariane Park Mark Stacy |
| author_facet | Ariane Park Mark Stacy |
| author_sort | Ariane Park |
| collection | DOAJ |
| description | Nonmotor symptoms of Parkinson's disease (PD) may emerge secondary to the underlying pathogenesis of the disease, while others are recognized side effects of treatment. Inevitably, there is an overlap as the disease advances and patients require higher dosages and more complex medical regimens. The non-motor symptoms that emerge secondary to dopaminergic therapy encompass several domains, including neuropsychiatric, autonomic, and sleep. These are detailed in the paper. Neuropsychiatric complications include hallucinations and psychosis. In addition, compulsive behaviors, such as pathological gambling, hypersexuality, shopping, binge eating, and punding, have been shown to have a clear association with dopaminergic medications. Dopamine dysregulation syndrome (DDS) is a compulsive behavior that is typically viewed through the lens of addiction, with patients needing escalating dosages of dopamine replacement therapy. Treatment side effects on the autonomic system include nausea, orthostatic hypotension, and constipation. Sleep disturbances include fragmented sleep, nighttime sleep problems, daytime sleepiness, and sleep attacks. Recognizing the non-motor symptoms that can arise specifically from dopamine therapy is useful to help optimize treatment regimens for this complex disease. |
| format | Article |
| id | doaj-art-7617cbe522364d5c906ffbccfe19e7ee |
| institution | OA Journals |
| issn | 2042-0080 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-7617cbe522364d5c906ffbccfe19e7ee2025-08-20T02:07:16ZengWileyParkinson's Disease2042-00802011-01-01201110.4061/2011/485063485063Dopamine-Induced Nonmotor Symptoms of Parkinson's DiseaseAriane Park0Mark Stacy1Department of Neurology, The Ohio State University, Columbus, OH 43210, USADivision of Neurology, Duke University Medical Center, Durham, NC 27705, USANonmotor symptoms of Parkinson's disease (PD) may emerge secondary to the underlying pathogenesis of the disease, while others are recognized side effects of treatment. Inevitably, there is an overlap as the disease advances and patients require higher dosages and more complex medical regimens. The non-motor symptoms that emerge secondary to dopaminergic therapy encompass several domains, including neuropsychiatric, autonomic, and sleep. These are detailed in the paper. Neuropsychiatric complications include hallucinations and psychosis. In addition, compulsive behaviors, such as pathological gambling, hypersexuality, shopping, binge eating, and punding, have been shown to have a clear association with dopaminergic medications. Dopamine dysregulation syndrome (DDS) is a compulsive behavior that is typically viewed through the lens of addiction, with patients needing escalating dosages of dopamine replacement therapy. Treatment side effects on the autonomic system include nausea, orthostatic hypotension, and constipation. Sleep disturbances include fragmented sleep, nighttime sleep problems, daytime sleepiness, and sleep attacks. Recognizing the non-motor symptoms that can arise specifically from dopamine therapy is useful to help optimize treatment regimens for this complex disease.http://dx.doi.org/10.4061/2011/485063 |
| spellingShingle | Ariane Park Mark Stacy Dopamine-Induced Nonmotor Symptoms of Parkinson's Disease Parkinson's Disease |
| title | Dopamine-Induced Nonmotor Symptoms of Parkinson's Disease |
| title_full | Dopamine-Induced Nonmotor Symptoms of Parkinson's Disease |
| title_fullStr | Dopamine-Induced Nonmotor Symptoms of Parkinson's Disease |
| title_full_unstemmed | Dopamine-Induced Nonmotor Symptoms of Parkinson's Disease |
| title_short | Dopamine-Induced Nonmotor Symptoms of Parkinson's Disease |
| title_sort | dopamine induced nonmotor symptoms of parkinson s disease |
| url | http://dx.doi.org/10.4061/2011/485063 |
| work_keys_str_mv | AT arianepark dopamineinducednonmotorsymptomsofparkinsonsdisease AT markstacy dopamineinducednonmotorsymptomsofparkinsonsdisease |