Generating a database by calculating the pathogenic variants and allele frequencies detected in hereditary cancers using genomic data: A nation study

Generating a database by calculating the pathogenic variants and allele frequencies detected in hereditary cancers using genomic data: A nation study

Background: Hereditary cancers are the consequence of inherited genetic variants that increase the risk of cancer development. The susceptibility to hereditary cancers can be increased by a combination of variable genes with different penetrance, such as BRCA1/2, which are common genes involved in s...

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Bibliographic Details
Main Authors: Manal Salah Babiker Ali, Polat OLGUN, Ömer DİKER, Kübra Damla EROL, İlkem Özce ÖZÇELİK, Mahmut Çerkez ERGÖREN
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-09-01
Series:Global Medical Genetics
Subjects:
Pathogenic variants
Hereditary cancer genes
Variant allele frequencies (VAF)
BRCA1/2
Online Access:http://www.sciencedirect.com/science/article/pii/S2699940425000530
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