Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients
Psoriasis is an inflammatory autoimmune disease characterized by cutaneous lesions in plaques. It has been proposed that the immune response has a key role in the disease progression. Particularly, the Th17 cells through IL-17 can contribute to maintain the inflammatory process. The pathogenic Th17...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/8065147 |
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| author | Cristina Aguilar-Flores Octavio Castro-Escamilla Elizabeth M. Ortega-Rocha César Maldonado-García Fermín Jurado-Santa Cruz Gibrán Pérez-Montesinos Alicia Lemini-López Laura C. Bonifaz |
| author_facet | Cristina Aguilar-Flores Octavio Castro-Escamilla Elizabeth M. Ortega-Rocha César Maldonado-García Fermín Jurado-Santa Cruz Gibrán Pérez-Montesinos Alicia Lemini-López Laura C. Bonifaz |
| author_sort | Cristina Aguilar-Flores |
| collection | DOAJ |
| description | Psoriasis is an inflammatory autoimmune disease characterized by cutaneous lesions in plaques. It has been proposed that the immune response has a key role in the disease progression. Particularly, the Th17 cells through IL-17 can contribute to maintain the inflammatory process. The pathogenic Th17 phenotype has been described in human diseases and associated with high severity in inflammatory experimental models. However, it is not clear if the pathogenic phenotype could be present in the skin and peripheral blood as well as its possible association to severity in psoriasis. In the lesional skin, we found high infiltration of Th17 cells and the pathogenic phenotype, finding a correlation between the frequency of Th17 cells and the Psoriasis Area and Severity Index (PASI) score. In peripheral blood, we observed a pool of Th17 lymphocytes with potential to acquire pathogenic features. Interestingly, the percentage of pathogenic Th17 cells (CD4+ RORγt+ IFN-γ+) correlates with disease severity. Moreover, we distinguished three groups of patients based on their IL-17/IFN-γ production by Th17 lymphocytes, which seems to be related with a dynamic or stable potential to express these cytokines. Remarkably, we evaluated the cytokine production by Th17 cells as an immunological marker for the adequate selection of biologic therapy. We found that patients analyzed by this immunological approach and treated with antibodies against IL-17 and TNFα showed great improvement depicted by reduction in PASI and Dermatology Life Quality Index (DLQI) score as well as the percentage of Body Surface Area (BSA). Altogether, our results highlight the importance of the assessment of the pathogenic phenotype in Th17 cells as an immune personalized analysis with the potential to support the therapy choice in the clinical practice. |
| format | Article |
| id | doaj-art-7612dc06f32845c298ba013aace17f2f |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7612dc06f32845c298ba013aace17f2f2025-08-20T02:07:16ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/80651478065147Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis PatientsCristina Aguilar-Flores0Octavio Castro-Escamilla1Elizabeth M. Ortega-Rocha2César Maldonado-García3Fermín Jurado-Santa Cruz4Gibrán Pérez-Montesinos5Alicia Lemini-López6Laura C. Bonifaz7Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI (CMNSXXI), Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI (CMNSXXI), Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI (CMNSXXI), Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoCentro Dermatológico “Dr. Ladislao de la Pascua”, Secretaria de Salud de la Ciudad de México, Mexico City 06780, MexicoCentro Dermatológico “Dr. Ladislao de la Pascua”, Secretaria de Salud de la Ciudad de México, Mexico City 06780, MexicoCentro Dermatológico “Dr. Ladislao de la Pascua”, Secretaria de Salud de la Ciudad de México, Mexico City 06780, MexicoServicio de Dermatología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI (CMNSXXI), Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoPsoriasis is an inflammatory autoimmune disease characterized by cutaneous lesions in plaques. It has been proposed that the immune response has a key role in the disease progression. Particularly, the Th17 cells through IL-17 can contribute to maintain the inflammatory process. The pathogenic Th17 phenotype has been described in human diseases and associated with high severity in inflammatory experimental models. However, it is not clear if the pathogenic phenotype could be present in the skin and peripheral blood as well as its possible association to severity in psoriasis. In the lesional skin, we found high infiltration of Th17 cells and the pathogenic phenotype, finding a correlation between the frequency of Th17 cells and the Psoriasis Area and Severity Index (PASI) score. In peripheral blood, we observed a pool of Th17 lymphocytes with potential to acquire pathogenic features. Interestingly, the percentage of pathogenic Th17 cells (CD4+ RORγt+ IFN-γ+) correlates with disease severity. Moreover, we distinguished three groups of patients based on their IL-17/IFN-γ production by Th17 lymphocytes, which seems to be related with a dynamic or stable potential to express these cytokines. Remarkably, we evaluated the cytokine production by Th17 cells as an immunological marker for the adequate selection of biologic therapy. We found that patients analyzed by this immunological approach and treated with antibodies against IL-17 and TNFα showed great improvement depicted by reduction in PASI and Dermatology Life Quality Index (DLQI) score as well as the percentage of Body Surface Area (BSA). Altogether, our results highlight the importance of the assessment of the pathogenic phenotype in Th17 cells as an immune personalized analysis with the potential to support the therapy choice in the clinical practice.http://dx.doi.org/10.1155/2020/8065147 |
| spellingShingle | Cristina Aguilar-Flores Octavio Castro-Escamilla Elizabeth M. Ortega-Rocha César Maldonado-García Fermín Jurado-Santa Cruz Gibrán Pérez-Montesinos Alicia Lemini-López Laura C. Bonifaz Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients Mediators of Inflammation |
| title | Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients |
| title_full | Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients |
| title_fullStr | Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients |
| title_full_unstemmed | Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients |
| title_short | Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients |
| title_sort | association of pathogenic th17 cells with the disease severity and its potential implication for biological treatment selection in psoriasis patients |
| url | http://dx.doi.org/10.1155/2020/8065147 |
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