Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts

DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex mixtures of carcinogens such as polycyclic aroma...

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Main Author: Bo Hang
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Journal of Nucleic Acids
Online Access:http://dx.doi.org/10.4061/2010/709521
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author Bo Hang
author_facet Bo Hang
author_sort Bo Hang
collection DOAJ
description DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex mixtures of carcinogens such as polycyclic aromatic hydrocarbons and N-nitrosamines. The bulky DNA adducts, which usually have complex structure, are particularly important because of their biological relevance. Several known cellular DNA repair pathways have been known to operate in human cells on specific types of bulky DNA adducts, for example, nucleotide excision repair, base excision repair, and direct reversal involving O6-alkylguanine DNA alkyltransferase or AlkB homologs. Understanding the mechanisms of adduct formation and repair processes is critical for the assessment of cancer risk resulting from exposure to cigarette smoke, and ultimately for developing strategies of cancer prevention. This paper highlights the recent progress made in the areas concerning formation and repair of bulky DNA adducts in the context of tobacco carcinogen-associated genotoxic and carcinogenic effects.
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spelling doaj-art-761191f018cd4f7caa033103195197c12025-02-03T07:24:07ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/709521709521Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA AdductsBo Hang0Life Sciences Division, Department of Cancer and DNA Damage Responses, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USADNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex mixtures of carcinogens such as polycyclic aromatic hydrocarbons and N-nitrosamines. The bulky DNA adducts, which usually have complex structure, are particularly important because of their biological relevance. Several known cellular DNA repair pathways have been known to operate in human cells on specific types of bulky DNA adducts, for example, nucleotide excision repair, base excision repair, and direct reversal involving O6-alkylguanine DNA alkyltransferase or AlkB homologs. Understanding the mechanisms of adduct formation and repair processes is critical for the assessment of cancer risk resulting from exposure to cigarette smoke, and ultimately for developing strategies of cancer prevention. This paper highlights the recent progress made in the areas concerning formation and repair of bulky DNA adducts in the context of tobacco carcinogen-associated genotoxic and carcinogenic effects.http://dx.doi.org/10.4061/2010/709521
spellingShingle Bo Hang
Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
Journal of Nucleic Acids
title Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
title_full Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
title_fullStr Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
title_full_unstemmed Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
title_short Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
title_sort formation and repair of tobacco carcinogen derived bulky dna adducts
url http://dx.doi.org/10.4061/2010/709521
work_keys_str_mv AT bohang formationandrepairoftobaccocarcinogenderivedbulkydnaadducts