The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis
Abstract Currently, an increasing number of individuals diagnosed with diabetes mellitus (DM) are opting for combined functional substances in edible plant products, like herbal prescription or traditional Chinese medicine (TCM), to enhance the efficacy of blood glucose and lipid profile control. Am...
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BMC
2025-07-01
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| Series: | Systematic Reviews |
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| Online Access: | https://doi.org/10.1186/s13643-025-02914-z |
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| author | Chongxiang Xue Ying Chen Cheng Tang Linhua Zhao Xiaolin Tong Han Wang |
| author_facet | Chongxiang Xue Ying Chen Cheng Tang Linhua Zhao Xiaolin Tong Han Wang |
| author_sort | Chongxiang Xue |
| collection | DOAJ |
| description | Abstract Currently, an increasing number of individuals diagnosed with diabetes mellitus (DM) are opting for combined functional substances in edible plant products, like herbal prescription or traditional Chinese medicine (TCM), to enhance the efficacy of blood glucose and lipid profile control. Among various TCM-included treatments available, Gegen Qinlian decoction (GQD) is frequently utilized. Nevertheless, the efficacy and safety of GQD and its main constituents (berberine, puerarin, etc.) in managing glucolipid metabolic disorders (GLMD) in DM remain under considerable debate. This overview aims to provide a concise summary of the key findings from systematic review and meta-analysis (SRMAs) on GQD and its main constituents for GLMD in DM, while also assessing the methodological quality of these reviews. A comprehensive search of online databases was conducted with no language restrictions, covering the period from inception to February 20th, 2025. The methodological quality, risk of bias, and strength of evidence of those included SRMAs were accessed. Overlapping randomized controlled trials (RCTs) were excluded, and the results of included meta-analysis were summarized. After screening, 35 studies matching the inclusion criteria were identified. The current evidence indicated that GQD, berberine, and puerarin appeared to be effective in improving the anti-diabetes role. As for blood lipid profile, it is indicated that GQD and berberine intervention could effectively reduce total cholesterol (TC), total triglycerides (TG), low-density lipoprotein (LDL-c) and increase high-density lipoprotein (HDL-c). Consequently, further high-quality primary studies are imperative to establish a more conclusive understanding of GQD and its main constituents for GLMD in DM. |
| format | Article |
| id | doaj-art-760cba38342a4a7583bf932d619e2f8c |
| institution | Kabale University |
| issn | 2046-4053 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj-art-760cba38342a4a7583bf932d619e2f8c2025-08-20T03:42:26ZengBMCSystematic Reviews2046-40532025-07-0114111610.1186/s13643-025-02914-zThe effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysisChongxiang Xue0Ying Chen1Cheng Tang2Linhua Zhao3Xiaolin Tong4Han Wang5Graduate School, Beijing University of Chinese MedicineGraduate School, Beijing University of Chinese MedicineBeijing Academy of Traditional Chinese Medicine, Beijing University of Chinese MedicineInstitute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing Academy of Traditional Chinese Medicine, Beijing University of Chinese MedicineSchool of Chinese Materia Medica, Beijing University of Chinese MedicineAbstract Currently, an increasing number of individuals diagnosed with diabetes mellitus (DM) are opting for combined functional substances in edible plant products, like herbal prescription or traditional Chinese medicine (TCM), to enhance the efficacy of blood glucose and lipid profile control. Among various TCM-included treatments available, Gegen Qinlian decoction (GQD) is frequently utilized. Nevertheless, the efficacy and safety of GQD and its main constituents (berberine, puerarin, etc.) in managing glucolipid metabolic disorders (GLMD) in DM remain under considerable debate. This overview aims to provide a concise summary of the key findings from systematic review and meta-analysis (SRMAs) on GQD and its main constituents for GLMD in DM, while also assessing the methodological quality of these reviews. A comprehensive search of online databases was conducted with no language restrictions, covering the period from inception to February 20th, 2025. The methodological quality, risk of bias, and strength of evidence of those included SRMAs were accessed. Overlapping randomized controlled trials (RCTs) were excluded, and the results of included meta-analysis were summarized. After screening, 35 studies matching the inclusion criteria were identified. The current evidence indicated that GQD, berberine, and puerarin appeared to be effective in improving the anti-diabetes role. As for blood lipid profile, it is indicated that GQD and berberine intervention could effectively reduce total cholesterol (TC), total triglycerides (TG), low-density lipoprotein (LDL-c) and increase high-density lipoprotein (HDL-c). Consequently, further high-quality primary studies are imperative to establish a more conclusive understanding of GQD and its main constituents for GLMD in DM.https://doi.org/10.1186/s13643-025-02914-zGlucolipid metabolic disordersDiabetes mellitusGegen Qinlian decoctionBerberinePuerarinOverview of systematic reviews and meta-analyses |
| spellingShingle | Chongxiang Xue Ying Chen Cheng Tang Linhua Zhao Xiaolin Tong Han Wang The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis Systematic Reviews Glucolipid metabolic disorders Diabetes mellitus Gegen Qinlian decoction Berberine Puerarin Overview of systematic reviews and meta-analyses |
| title | The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis |
| title_full | The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis |
| title_fullStr | The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis |
| title_full_unstemmed | The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis |
| title_short | The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis |
| title_sort | effects of gegen qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes an overview of systematic reviews and meta analysis |
| topic | Glucolipid metabolic disorders Diabetes mellitus Gegen Qinlian decoction Berberine Puerarin Overview of systematic reviews and meta-analyses |
| url | https://doi.org/10.1186/s13643-025-02914-z |
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