A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoni
The increased pathogenesis of the Schistosoma mansoni BH strain compared with the SJ strain has been attributed to the number of granulomas formed in experimental infections, which increase the mortality in definitive hosts. The aim of the present study was to investigate the development of granulom...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2012/953524 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565241342328832 |
|---|---|
| author | Nádia Regina Borim Zuim Silmara Marques Allegretti Arício Xavier Linhares Luiz Augusto Magalhães Eliana Maria Zanotti-Magalhães |
| author_facet | Nádia Regina Borim Zuim Silmara Marques Allegretti Arício Xavier Linhares Luiz Augusto Magalhães Eliana Maria Zanotti-Magalhães |
| author_sort | Nádia Regina Borim Zuim |
| collection | DOAJ |
| description | The increased pathogenesis of the Schistosoma mansoni BH strain compared with the SJ strain has been attributed to the number of granulomas formed in experimental infections, which increase the mortality in definitive hosts. The aim of the present study was to investigate the development of granulomas around the eggs of the S. mansoni BH and SJ strains and to determine whether this host reaction was strain specific. Four experimental groups were analyzed. Two groups contained mice inoculated in the caudal vein with eggs from the S. mansoni BH or SJ strains and the other two contained mice that were infected with cercariae of the BH strain prior to being inoculated with eggs. The number of granulomas per tissue area in the lungs and liver, as well as the size of the granulomas, was analyzed to characterize the response to schistosome infection. The largest granulomatous responses were observed around eggs of the BH strain. Granulomas covered a larger area in the lungs of mice that were previously infected with cercariae and subsequently inoculated with eggs of the BH strain. These results indicated that specific granulomatous responses occurred following an infection with the BH and SJ strains of S. mansoni. |
| format | Article |
| id | doaj-art-7607648b3fb042f79a94778f621a33b9 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-7607648b3fb042f79a94778f621a33b92025-02-03T01:08:56ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982012-01-01201210.1155/2012/953524953524A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoniNádia Regina Borim Zuim0Silmara Marques Allegretti1Arício Xavier Linhares2Luiz Augusto Magalhães3Eliana Maria Zanotti-Magalhães4Department of Animal Biology, Institute of Biology, State University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Rua Monteiro Lobato 255, 13083-862 Campinas, SP, BrazilDepartment of Animal Biology, Institute of Biology, State University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Rua Monteiro Lobato 255, 13083-862 Campinas, SP, BrazilDepartment of Animal Biology, Institute of Biology, State University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Rua Monteiro Lobato 255, 13083-862 Campinas, SP, BrazilDepartment of Animal Biology, Institute of Biology, State University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Rua Monteiro Lobato 255, 13083-862 Campinas, SP, BrazilDepartment of Animal Biology, Institute of Biology, State University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Rua Monteiro Lobato 255, 13083-862 Campinas, SP, BrazilThe increased pathogenesis of the Schistosoma mansoni BH strain compared with the SJ strain has been attributed to the number of granulomas formed in experimental infections, which increase the mortality in definitive hosts. The aim of the present study was to investigate the development of granulomas around the eggs of the S. mansoni BH and SJ strains and to determine whether this host reaction was strain specific. Four experimental groups were analyzed. Two groups contained mice inoculated in the caudal vein with eggs from the S. mansoni BH or SJ strains and the other two contained mice that were infected with cercariae of the BH strain prior to being inoculated with eggs. The number of granulomas per tissue area in the lungs and liver, as well as the size of the granulomas, was analyzed to characterize the response to schistosome infection. The largest granulomatous responses were observed around eggs of the BH strain. Granulomas covered a larger area in the lungs of mice that were previously infected with cercariae and subsequently inoculated with eggs of the BH strain. These results indicated that specific granulomatous responses occurred following an infection with the BH and SJ strains of S. mansoni.http://dx.doi.org/10.1155/2012/953524 |
| spellingShingle | Nádia Regina Borim Zuim Silmara Marques Allegretti Arício Xavier Linhares Luiz Augusto Magalhães Eliana Maria Zanotti-Magalhães A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoni Interdisciplinary Perspectives on Infectious Diseases |
| title | A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoni |
| title_full | A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoni |
| title_fullStr | A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoni |
| title_full_unstemmed | A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoni |
| title_short | A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoni |
| title_sort | study of the granulomatous responses induced by different strains of schistosoma mansoni |
| url | http://dx.doi.org/10.1155/2012/953524 |
| work_keys_str_mv | AT nadiareginaborimzuim astudyofthegranulomatousresponsesinducedbydifferentstrainsofschistosomamansoni AT silmaramarquesallegretti astudyofthegranulomatousresponsesinducedbydifferentstrainsofschistosomamansoni AT aricioxavierlinhares astudyofthegranulomatousresponsesinducedbydifferentstrainsofschistosomamansoni AT luizaugustomagalhaes astudyofthegranulomatousresponsesinducedbydifferentstrainsofschistosomamansoni AT elianamariazanottimagalhaes astudyofthegranulomatousresponsesinducedbydifferentstrainsofschistosomamansoni AT nadiareginaborimzuim studyofthegranulomatousresponsesinducedbydifferentstrainsofschistosomamansoni AT silmaramarquesallegretti studyofthegranulomatousresponsesinducedbydifferentstrainsofschistosomamansoni AT aricioxavierlinhares studyofthegranulomatousresponsesinducedbydifferentstrainsofschistosomamansoni AT luizaugustomagalhaes studyofthegranulomatousresponsesinducedbydifferentstrainsofschistosomamansoni AT elianamariazanottimagalhaes studyofthegranulomatousresponsesinducedbydifferentstrainsofschistosomamansoni |