Anti-IFN-γ Autoantibody Syndrome Presenting with Disseminated Nontuberculous Mycobacteria Infections: A Case Series of Therapeutic Implications and Review of Literature

Anti-IFN-γ Autoantibody Syndrome Presenting with Disseminated Nontuberculous Mycobacteria Infections: A Case Series of Therapeutic Implications and Review of Literature

Anticytokine autoantibodies (AAbs), particularly anti-interferon-gamma (anti-IFN-γ) AAbs, disrupt cytokine functions, leading to infections, autoimmune-like diseases, and conditions resembling interleukin-12 (IL-12)/IFN-γ pathway defects. Advances in genetic testing have clarified overlaps between a...

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Bibliographic Details
Main Authors: Brooke Cheng, Barinder Bajwa, Seungwon Choi, Hannah Martin, Tyson Miao, Denise Werry, Michael Perlman, Yazdan Mirzanejad
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Tropical Medicine and Infectious Disease
Subjects:
mycobacterium avium complex
nontuberculous mycobacteria
rituximab
interferon gamma
immune deficiency
case series
Online Access:https://www.mdpi.com/2414-6366/10/7/202
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