Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models

Bombax costatum (Bombacaceae) is traditionally used as a decoction of the leaves, stem, and root to treat headaches, fever, and oedema that may be associated with inflammatory conditions. Thus, the aim of this study was to evaluate the effect of 70%v/v ethanolic extract of the stem bark of Bombax co...

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Main Authors: Meshack Antwi-Adjei, Kofi Oduro Yeboah, James Oppong-Kyekyeku, Newman Osafo
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Scientifica
Online Access:http://dx.doi.org/10.1155/2022/6882147
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author Meshack Antwi-Adjei
Kofi Oduro Yeboah
James Oppong-Kyekyeku
Newman Osafo
author_facet Meshack Antwi-Adjei
Kofi Oduro Yeboah
James Oppong-Kyekyeku
Newman Osafo
author_sort Meshack Antwi-Adjei
collection DOAJ
description Bombax costatum (Bombacaceae) is traditionally used as a decoction of the leaves, stem, and root to treat headaches, fever, and oedema that may be associated with inflammatory conditions. Thus, the aim of this study was to evaluate the effect of 70%v/v ethanolic extract of the stem bark of Bombax costatum on acute and chronic inflammation. The effect of Bombax costatum extract (10, 50, 100 mg kg−1, p.o) was studied in prostaglandin E2-induced paw oedema in Sprague–Dawley rats (n = 5). Subsequently, the effect of the extract on clonidine and haloperidol-induced catalepsy was also investigated in ICR mice (n = 5). Finally, the ability of the extract to inhibit chronic inflammation was studied using a rat adjuvant-induced arthritis model. Pre-emptive and therapeutic administration of the extract at all doses significantly suppressed the formation of oedema following prostaglandin E2 administration. As a measure of indirect antihistaminic effect, treatment with the extract suppressed clonidine-induced catalepsy but not haloperidol-induced catalepsy. Moreover, Bombax costatum extract significantly inhibited joint inflammation and damage following injection of complete Freund’s adjuvant. Treatment with the extract also inhibited the onset of polyarthritis; thus, suppressing the systemic spread of joint inflammation from ipsilateral limbs to contralateral limbs. In conclusion, the hydroethanol extract of the stem bark of Bombax costatum inhibits both acute and chronic inflammation.
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spelling doaj-art-75fada657fe84cb09f00aa8ab2d232d52025-02-03T06:04:53ZengWileyScientifica2090-908X2022-01-01202210.1155/2022/6882147Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine ModelsMeshack Antwi-Adjei0Kofi Oduro Yeboah1James Oppong-Kyekyeku2Newman Osafo3Department of PharmacologyDepartment of PharmacologyDepartment of Pharmaceutical ChemistryDepartment of PharmacologyBombax costatum (Bombacaceae) is traditionally used as a decoction of the leaves, stem, and root to treat headaches, fever, and oedema that may be associated with inflammatory conditions. Thus, the aim of this study was to evaluate the effect of 70%v/v ethanolic extract of the stem bark of Bombax costatum on acute and chronic inflammation. The effect of Bombax costatum extract (10, 50, 100 mg kg−1, p.o) was studied in prostaglandin E2-induced paw oedema in Sprague–Dawley rats (n = 5). Subsequently, the effect of the extract on clonidine and haloperidol-induced catalepsy was also investigated in ICR mice (n = 5). Finally, the ability of the extract to inhibit chronic inflammation was studied using a rat adjuvant-induced arthritis model. Pre-emptive and therapeutic administration of the extract at all doses significantly suppressed the formation of oedema following prostaglandin E2 administration. As a measure of indirect antihistaminic effect, treatment with the extract suppressed clonidine-induced catalepsy but not haloperidol-induced catalepsy. Moreover, Bombax costatum extract significantly inhibited joint inflammation and damage following injection of complete Freund’s adjuvant. Treatment with the extract also inhibited the onset of polyarthritis; thus, suppressing the systemic spread of joint inflammation from ipsilateral limbs to contralateral limbs. In conclusion, the hydroethanol extract of the stem bark of Bombax costatum inhibits both acute and chronic inflammation.http://dx.doi.org/10.1155/2022/6882147
spellingShingle Meshack Antwi-Adjei
Kofi Oduro Yeboah
James Oppong-Kyekyeku
Newman Osafo
Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models
Scientifica
title Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models
title_full Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models
title_fullStr Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models
title_full_unstemmed Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models
title_short Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models
title_sort inflammation modulating activity of the hydroethanol stem bark extract of bombax costatum in murine models
url http://dx.doi.org/10.1155/2022/6882147
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AT jamesoppongkyekyeku inflammationmodulatingactivityofthehydroethanolstembarkextractofbombaxcostatuminmurinemodels
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