Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based study
Abstract Given the increasing trend of cholecystectomy, it is imperative to reassess surgical and surveillance strategies in consideration of the potential long-term risks for digestive tract cancers. The objective of this study was to assess the risk of gastrointestinal (GI) and hepato-biliary-panc...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84781-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559603298435072 |
|---|---|
| author | Young Ae Kim Hak Jun Kim Mee Joo Kang Sung-Sik Han Hyeong Min Park Sang-Jae Park |
| author_facet | Young Ae Kim Hak Jun Kim Mee Joo Kang Sung-Sik Han Hyeong Min Park Sang-Jae Park |
| author_sort | Young Ae Kim |
| collection | DOAJ |
| description | Abstract Given the increasing trend of cholecystectomy, it is imperative to reassess surgical and surveillance strategies in consideration of the potential long-term risks for digestive tract cancers. The objective of this study was to assess the risk of gastrointestinal (GI) and hepato-biliary-pancreatic (HBP) cancer incidence after cholecystectomy. The data for this cohort study was obtained from the National Health Insurance Service database in Korea. 715,872 patients who underwent cholecystectomy between 2004 and 2020 were compared to 1,431,728 individuals who did not underwent cholecystectomy after age, sex, and year of cholecystectomy was matched. The overall incidence rate ratio (IRR) for all GI and HBP cancers was 1.08 (95% C.I., 1.06–1.10). Specifically, the risk of diagnosis of extrahepatic bile duct cancer (IRR 1.92), intrahepatic bile duct cancer (1.78), hepatocellular carcinoma (1.22), and pancreatic cancer (1.13) was significantly increased in the cholecystectomy group. The highest IRR was observed within the 1–3 years following cholecystectomy. Subsequently, the risk of diagnosis gradually decreased and returned to a level comparable to that of the matched control group after 5 to 10 years. In conclusion, hepato-biliary-pancreatic cancer are frequently diagnosed subsequent to cholecystectomy. Too short period of post-cholecystectomy follow-up may hinder monitoring of hepato-biliary-pancreatic cancer occurrence. |
| format | Article |
| id | doaj-art-75fa43eb8d224ec1aeebc00f904995f9 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-75fa43eb8d224ec1aeebc00f904995f92025-01-05T12:20:51ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-84781-7Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based studyYoung Ae Kim0Hak Jun Kim1Mee Joo Kang2Sung-Sik Han3Hyeong Min Park4Sang-Jae Park5Division of Cancer Control & Policy, National Cancer Control Institute, National Cancer CenterDivision of Cancer Control & Policy, National Cancer Control Institute, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterAbstract Given the increasing trend of cholecystectomy, it is imperative to reassess surgical and surveillance strategies in consideration of the potential long-term risks for digestive tract cancers. The objective of this study was to assess the risk of gastrointestinal (GI) and hepato-biliary-pancreatic (HBP) cancer incidence after cholecystectomy. The data for this cohort study was obtained from the National Health Insurance Service database in Korea. 715,872 patients who underwent cholecystectomy between 2004 and 2020 were compared to 1,431,728 individuals who did not underwent cholecystectomy after age, sex, and year of cholecystectomy was matched. The overall incidence rate ratio (IRR) for all GI and HBP cancers was 1.08 (95% C.I., 1.06–1.10). Specifically, the risk of diagnosis of extrahepatic bile duct cancer (IRR 1.92), intrahepatic bile duct cancer (1.78), hepatocellular carcinoma (1.22), and pancreatic cancer (1.13) was significantly increased in the cholecystectomy group. The highest IRR was observed within the 1–3 years following cholecystectomy. Subsequently, the risk of diagnosis gradually decreased and returned to a level comparable to that of the matched control group after 5 to 10 years. In conclusion, hepato-biliary-pancreatic cancer are frequently diagnosed subsequent to cholecystectomy. Too short period of post-cholecystectomy follow-up may hinder monitoring of hepato-biliary-pancreatic cancer occurrence.https://doi.org/10.1038/s41598-024-84781-7CholecystectomyCancerIncidenceBile duct neoplasmsLiverPancreas |
| spellingShingle | Young Ae Kim Hak Jun Kim Mee Joo Kang Sung-Sik Han Hyeong Min Park Sang-Jae Park Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based study Scientific Reports Cholecystectomy Cancer Incidence Bile duct neoplasms Liver Pancreas |
| title | Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based study |
| title_full | Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based study |
| title_fullStr | Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based study |
| title_full_unstemmed | Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based study |
| title_short | Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based study |
| title_sort | increased diagnosis of hepato biliary pancreatic cancer after cholecystectomy a population based study |
| topic | Cholecystectomy Cancer Incidence Bile duct neoplasms Liver Pancreas |
| url | https://doi.org/10.1038/s41598-024-84781-7 |
| work_keys_str_mv | AT youngaekim increaseddiagnosisofhepatobiliarypancreaticcanceraftercholecystectomyapopulationbasedstudy AT hakjunkim increaseddiagnosisofhepatobiliarypancreaticcanceraftercholecystectomyapopulationbasedstudy AT meejookang increaseddiagnosisofhepatobiliarypancreaticcanceraftercholecystectomyapopulationbasedstudy AT sungsikhan increaseddiagnosisofhepatobiliarypancreaticcanceraftercholecystectomyapopulationbasedstudy AT hyeongminpark increaseddiagnosisofhepatobiliarypancreaticcanceraftercholecystectomyapopulationbasedstudy AT sangjaepark increaseddiagnosisofhepatobiliarypancreaticcanceraftercholecystectomyapopulationbasedstudy |