Functional Fcgamma receptor polymorphisms are associated with human allergy.
<h4>Objective</h4>IgG Fc receptors (FcγRs) play important roles in immune responses. It is not clear whether FcγR receptors play a role in human asthma and allergy. The aim of current study was to investigate whether functional single nucleotide polymorphisms (SNPs) of FcγR genes (FCGR)...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089196&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849720481037418496 |
|---|---|
| author | Jianming Wu Rui Lin Jinhai Huang Weihua Guan William S Oetting P Sriramarao Malcolm N Blumenthal |
| author_facet | Jianming Wu Rui Lin Jinhai Huang Weihua Guan William S Oetting P Sriramarao Malcolm N Blumenthal |
| author_sort | Jianming Wu |
| collection | DOAJ |
| description | <h4>Objective</h4>IgG Fc receptors (FcγRs) play important roles in immune responses. It is not clear whether FcγR receptors play a role in human asthma and allergy. The aim of current study was to investigate whether functional single nucleotide polymorphisms (SNPs) of FcγR genes (FCGR) are associated with human asthma and allergy.<h4>Methods</h4>Functional SNPs of FCGR2A (FcγRIIA-131His>Arg, rs1801274), FCGR2B (FcγRIIB-187Ile>Thr, rs1050501), FCGR2C (FcγRIIC-13Gln>Stop, rs10917661), FCGR3A (FcγRIIIA-158Val>Phe, rs396991), and FCGR3B variants (FcγRIIIB NA1 and NA2) were genotyped in an asthma family cohort including 370 atopy positive, 239 atopy negative, and 169 asthma positive subjects. The genotype and phenotype data (asthma, bronchial hyper-responsiveness, and atopy) of subjects were analyzed using family-based association tests (FBAT) and logistic regression adjusted for age and sex.<h4>Result</h4>The FcγRIIA-131His>Arg SNP is significantly associated with atopy in a family-based association test (P = 0.00287) and in a logistic regression analysis (P = 0.0269, OR 0.732, 95% CI: 0.555-0.965). The FcγRIIA-131His (or rs1801274-A) allele capable of binding human IgG2 has a protective role against atopy. In addition, the rare FcγRIIB-187Thr (or rs1050501-C) allele defective for the receptor-mediated inhibitory signals is a risk factor for atopy (P = 0.0031, OR 1.758, 95% CI: 1.209-2.556) and IgE production (P<0.001). However, variants of activating FcγRIIIA (rs396991), and FcγRIIIB (NA1 and NA2), and FcγRIIC (rs10917661) are not associated with asthma, BHR, and atopy (P>0.05).<h4>Conclusions</h4>FcγRIIA and FcγRIIB functional polymorphisms may have a role in the pathogenesis of allergy. |
| format | Article |
| id | doaj-art-75f449eaebe34a4fa79cd803dbe234ce |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-75f449eaebe34a4fa79cd803dbe234ce2025-08-20T03:11:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8919610.1371/journal.pone.0089196Functional Fcgamma receptor polymorphisms are associated with human allergy.Jianming WuRui LinJinhai HuangWeihua GuanWilliam S OettingP SriramaraoMalcolm N Blumenthal<h4>Objective</h4>IgG Fc receptors (FcγRs) play important roles in immune responses. It is not clear whether FcγR receptors play a role in human asthma and allergy. The aim of current study was to investigate whether functional single nucleotide polymorphisms (SNPs) of FcγR genes (FCGR) are associated with human asthma and allergy.<h4>Methods</h4>Functional SNPs of FCGR2A (FcγRIIA-131His>Arg, rs1801274), FCGR2B (FcγRIIB-187Ile>Thr, rs1050501), FCGR2C (FcγRIIC-13Gln>Stop, rs10917661), FCGR3A (FcγRIIIA-158Val>Phe, rs396991), and FCGR3B variants (FcγRIIIB NA1 and NA2) were genotyped in an asthma family cohort including 370 atopy positive, 239 atopy negative, and 169 asthma positive subjects. The genotype and phenotype data (asthma, bronchial hyper-responsiveness, and atopy) of subjects were analyzed using family-based association tests (FBAT) and logistic regression adjusted for age and sex.<h4>Result</h4>The FcγRIIA-131His>Arg SNP is significantly associated with atopy in a family-based association test (P = 0.00287) and in a logistic regression analysis (P = 0.0269, OR 0.732, 95% CI: 0.555-0.965). The FcγRIIA-131His (or rs1801274-A) allele capable of binding human IgG2 has a protective role against atopy. In addition, the rare FcγRIIB-187Thr (or rs1050501-C) allele defective for the receptor-mediated inhibitory signals is a risk factor for atopy (P = 0.0031, OR 1.758, 95% CI: 1.209-2.556) and IgE production (P<0.001). However, variants of activating FcγRIIIA (rs396991), and FcγRIIIB (NA1 and NA2), and FcγRIIC (rs10917661) are not associated with asthma, BHR, and atopy (P>0.05).<h4>Conclusions</h4>FcγRIIA and FcγRIIB functional polymorphisms may have a role in the pathogenesis of allergy.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089196&type=printable |
| spellingShingle | Jianming Wu Rui Lin Jinhai Huang Weihua Guan William S Oetting P Sriramarao Malcolm N Blumenthal Functional Fcgamma receptor polymorphisms are associated with human allergy. PLoS ONE |
| title | Functional Fcgamma receptor polymorphisms are associated with human allergy. |
| title_full | Functional Fcgamma receptor polymorphisms are associated with human allergy. |
| title_fullStr | Functional Fcgamma receptor polymorphisms are associated with human allergy. |
| title_full_unstemmed | Functional Fcgamma receptor polymorphisms are associated with human allergy. |
| title_short | Functional Fcgamma receptor polymorphisms are associated with human allergy. |
| title_sort | functional fcgamma receptor polymorphisms are associated with human allergy |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089196&type=printable |
| work_keys_str_mv | AT jianmingwu functionalfcgammareceptorpolymorphismsareassociatedwithhumanallergy AT ruilin functionalfcgammareceptorpolymorphismsareassociatedwithhumanallergy AT jinhaihuang functionalfcgammareceptorpolymorphismsareassociatedwithhumanallergy AT weihuaguan functionalfcgammareceptorpolymorphismsareassociatedwithhumanallergy AT williamsoetting functionalfcgammareceptorpolymorphismsareassociatedwithhumanallergy AT psriramarao functionalfcgammareceptorpolymorphismsareassociatedwithhumanallergy AT malcolmnblumenthal functionalfcgammareceptorpolymorphismsareassociatedwithhumanallergy |