Sex-specific differences of advanced glycation end products in diabetes
Abstract Advanced glycation end products (AGEs) are formed through non-enzymatic glycation reactions and accumulate in tissues, particularly under pathological conditions such as diabetes mellitus. These compounds are linked to the progression of diabetic complications, including nephropathy, retino...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-06-01
|
| Series: | Nutrition & Diabetes |
| Online Access: | https://doi.org/10.1038/s41387-025-00379-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850221768610938880 |
|---|---|
| author | Michael Hellwig Julia Decker Leticia Prates Roma Stefan Schunk Emmanuel Ampofo Sandra Rother |
| author_facet | Michael Hellwig Julia Decker Leticia Prates Roma Stefan Schunk Emmanuel Ampofo Sandra Rother |
| author_sort | Michael Hellwig |
| collection | DOAJ |
| description | Abstract Advanced glycation end products (AGEs) are formed through non-enzymatic glycation reactions and accumulate in tissues, particularly under pathological conditions such as diabetes mellitus. These compounds are linked to the progression of diabetic complications, including nephropathy, retinopathy, and cardiovascular disease, through mechanisms such as oxidative stress and chronic inflammation. Emerging evidence suggests significant sex-specific differences in AGE formation, accumulation, and their biological effects, influenced by hormonal variations, dietary patterns, and metabolic differences. While the underlying biochemistry of AGE formation, such as the Maillard reaction and dicarbonyl compound activity, is well-characterized, the implications of these processes for clinical outcomes remain underexplored. This mini-review highlights the interplay between molecular mechanisms and sex-specific factors in AGE-related pathophysiology. It further discusses potential therapeutic approaches targeting AGE formation and receptor-mediated pathways, emphasizing the importance of integrating sex-specific considerations into diabetes management. Bridging molecular insights with clinical practice could advance personalized treatment strategies for diabetic complications. |
| format | Article |
| id | doaj-art-75effd5f141644faa104f67154a2beef |
| institution | OA Journals |
| issn | 2044-4052 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Nutrition & Diabetes |
| spelling | doaj-art-75effd5f141644faa104f67154a2beef2025-08-20T02:06:36ZengNature Publishing GroupNutrition & Diabetes2044-40522025-06-011511810.1038/s41387-025-00379-6Sex-specific differences of advanced glycation end products in diabetesMichael Hellwig0Julia Decker1Leticia Prates Roma2Stefan Schunk3Emmanuel Ampofo4Sandra Rother5Professur für Spezielle Lebensmittelchemie, Technische Universität DresdenInstitute of Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), Saarland UniversityInstitute of Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), Saarland UniversityCenter for Gender-specific Biology and Medicine (CGBM), Saarland UniversityCenter for Gender-specific Biology and Medicine (CGBM), Saarland UniversityInstitute of Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), Saarland UniversityAbstract Advanced glycation end products (AGEs) are formed through non-enzymatic glycation reactions and accumulate in tissues, particularly under pathological conditions such as diabetes mellitus. These compounds are linked to the progression of diabetic complications, including nephropathy, retinopathy, and cardiovascular disease, through mechanisms such as oxidative stress and chronic inflammation. Emerging evidence suggests significant sex-specific differences in AGE formation, accumulation, and their biological effects, influenced by hormonal variations, dietary patterns, and metabolic differences. While the underlying biochemistry of AGE formation, such as the Maillard reaction and dicarbonyl compound activity, is well-characterized, the implications of these processes for clinical outcomes remain underexplored. This mini-review highlights the interplay between molecular mechanisms and sex-specific factors in AGE-related pathophysiology. It further discusses potential therapeutic approaches targeting AGE formation and receptor-mediated pathways, emphasizing the importance of integrating sex-specific considerations into diabetes management. Bridging molecular insights with clinical practice could advance personalized treatment strategies for diabetic complications.https://doi.org/10.1038/s41387-025-00379-6 |
| spellingShingle | Michael Hellwig Julia Decker Leticia Prates Roma Stefan Schunk Emmanuel Ampofo Sandra Rother Sex-specific differences of advanced glycation end products in diabetes Nutrition & Diabetes |
| title | Sex-specific differences of advanced glycation end products in diabetes |
| title_full | Sex-specific differences of advanced glycation end products in diabetes |
| title_fullStr | Sex-specific differences of advanced glycation end products in diabetes |
| title_full_unstemmed | Sex-specific differences of advanced glycation end products in diabetes |
| title_short | Sex-specific differences of advanced glycation end products in diabetes |
| title_sort | sex specific differences of advanced glycation end products in diabetes |
| url | https://doi.org/10.1038/s41387-025-00379-6 |
| work_keys_str_mv | AT michaelhellwig sexspecificdifferencesofadvancedglycationendproductsindiabetes AT juliadecker sexspecificdifferencesofadvancedglycationendproductsindiabetes AT leticiapratesroma sexspecificdifferencesofadvancedglycationendproductsindiabetes AT stefanschunk sexspecificdifferencesofadvancedglycationendproductsindiabetes AT emmanuelampofo sexspecificdifferencesofadvancedglycationendproductsindiabetes AT sandrarother sexspecificdifferencesofadvancedglycationendproductsindiabetes |