Novel NIR fluorescent probe IR-546 inhibits melanoma through the AKT/GSK3β/β-catenin pathway

Novel NIR fluorescent probe IR-546 inhibits melanoma through the AKT/GSK3β/β-catenin pathway

Abstract Background Melanoma is a highly invasive and metastatic skin cancer lacking effective options for early diagnosis and treatment. To address these challenges, this study aimed to synthesize a novel near-infrared fluorescent probe and research the antitumor mechanism of melanoma. Methods We h...

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Bibliographic Details
Main Authors: Hongye Liao, Tong Xia, Ziyuan Zeng, Xun Yang, Simei Yang, Xia Xiong, Yuanmin He, Changzhen Sun, Na Hao, Li Liu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
Near-infrared (NIR) fluorescent probe
Malignant melanoma
Apoptosis
Cyanine dyes
Mitochondrial-targeted
Online Access:https://doi.org/10.1186/s10020-025-01289-0
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