A Subgroup of First-Degree Relatives of Crohn's Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which Is More Typical of Crohn's Disease Patients Than of Normal Individuals
Introduction. Family member with IBD is the greatest risk factor for developing the disease. The hematological profileof first-degree relatives (FDRs) of Crohn's disease (CD) patients was studied in order to identify healthy FDRs at risk to develop disease. Materials and methods. Thirty CD pati...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/74785 |
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| author | Broide Efrat Goren Iris Hongbin Wang Scapa Eitan Keisari Yona |
| author_facet | Broide Efrat Goren Iris Hongbin Wang Scapa Eitan Keisari Yona |
| author_sort | Broide Efrat |
| collection | DOAJ |
| description | Introduction. Family member with IBD is the greatest risk factor for developing the disease. The hematological profileof first-degree relatives (FDRs) of Crohn's disease (CD) patients was studied in order to identify healthy FDRs at risk to develop disease. Materials and methods. Thirty CD
patients, 90 FDRs, and 28 non-related individuals (controls) were enrolled. Hematological profile and C-reactive protein were determined. Results. All hematological parameters were significantly different in CD patients compared to controls, with significantly higher levels of CRP, WBC, PMN, MONO, and PLT and
lower Hb and lymphocyte count. The hematological profile of FDRs showed values between the controls and CD patients with ten FDRs that their parameters matched those of CD patients and significantly different from other FDRs. This group was defined as high-risk relatives (HRRs). Conclusions. Analysis of the hematological profile and CRP level might be proven as a fast,
reliable, and less money-consuming tool to identify FDRs with a probable increased risk to develop the disease. |
| format | Article |
| id | doaj-art-75e949a21e4d4bf99f48e6d9b5f41e49 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-75e949a21e4d4bf99f48e6d9b5f41e492025-02-03T05:59:52ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/7478574785A Subgroup of First-Degree Relatives of Crohn's Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which Is More Typical of Crohn's Disease Patients Than of Normal IndividualsBroide Efrat0Goren Iris1Hongbin Wang2Scapa Eitan3Keisari Yona4Gastroenterology Institute, Assaf Harofeh Medical Center, Zerifin 70300, IsraelGastroenterology Institute, Assaf Harofeh Medical Center, Zerifin 70300, IsraelDepartment of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, IsraelGastroenterology Institute, Assaf Harofeh Medical Center, Zerifin 70300, IsraelDepartment of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, IsraelIntroduction. Family member with IBD is the greatest risk factor for developing the disease. The hematological profileof first-degree relatives (FDRs) of Crohn's disease (CD) patients was studied in order to identify healthy FDRs at risk to develop disease. Materials and methods. Thirty CD patients, 90 FDRs, and 28 non-related individuals (controls) were enrolled. Hematological profile and C-reactive protein were determined. Results. All hematological parameters were significantly different in CD patients compared to controls, with significantly higher levels of CRP, WBC, PMN, MONO, and PLT and lower Hb and lymphocyte count. The hematological profile of FDRs showed values between the controls and CD patients with ten FDRs that their parameters matched those of CD patients and significantly different from other FDRs. This group was defined as high-risk relatives (HRRs). Conclusions. Analysis of the hematological profile and CRP level might be proven as a fast, reliable, and less money-consuming tool to identify FDRs with a probable increased risk to develop the disease.http://dx.doi.org/10.1155/MI/2006/74785 |
| spellingShingle | Broide Efrat Goren Iris Hongbin Wang Scapa Eitan Keisari Yona A Subgroup of First-Degree Relatives of Crohn's Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which Is More Typical of Crohn's Disease Patients Than of Normal Individuals Mediators of Inflammation |
| title | A Subgroup of First-Degree Relatives of Crohn's Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which Is More Typical of Crohn's Disease Patients Than of Normal Individuals |
| title_full | A Subgroup of First-Degree Relatives of Crohn's Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which Is More Typical of Crohn's Disease Patients Than of Normal Individuals |
| title_fullStr | A Subgroup of First-Degree Relatives of Crohn's Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which Is More Typical of Crohn's Disease Patients Than of Normal Individuals |
| title_full_unstemmed | A Subgroup of First-Degree Relatives of Crohn's Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which Is More Typical of Crohn's Disease Patients Than of Normal Individuals |
| title_short | A Subgroup of First-Degree Relatives of Crohn's Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which Is More Typical of Crohn's Disease Patients Than of Normal Individuals |
| title_sort | subgroup of first degree relatives of crohn s disease patients shows a profile of inflammatory markers in the blood which is more typical of crohn s disease patients than of normal individuals |
| url | http://dx.doi.org/10.1155/MI/2006/74785 |
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