Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion
Abstract The crosstalk between immunity and cancer in the regulation of tumor growth is considered a hallmark of cancer. Antitumor immunity refers to the innate and adaptive immune responses that regulate cancer development and proliferation. Tumor immune evasion represents a major hindrance to effe...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202417357 |
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| author | Xuanfan Liu Kenneth K.W. To Qinsong Zeng Liwu Fu |
| author_facet | Xuanfan Liu Kenneth K.W. To Qinsong Zeng Liwu Fu |
| author_sort | Xuanfan Liu |
| collection | DOAJ |
| description | Abstract The crosstalk between immunity and cancer in the regulation of tumor growth is considered a hallmark of cancer. Antitumor immunity refers to the innate and adaptive immune responses that regulate cancer development and proliferation. Tumor immune evasion represents a major hindrance to effective anticancer treatment. Extracellular vesicles (EVs) are nano‐sized and lipid‐bilayer‐enclosed particles that are secreted to the extracellular space by all cell types. They are critically involved in numerous biological functions including intercellular communication. Tumor‐derived extracellular vesicles (TEVs) can transport a variety of cargo to modulate immune cells in the tumor microenvironment (TME). This review provides the latest update about how tumor cells evade immune surveillance by exploiting TEVs. First, the biogenesis of EVs and the cargo‐sorting machinery are discussed. Second, how tumor cells modulate immune cell differentiation, activation, and function via TEVs to evade immune surveillance is illustrated. Last but not least, the novel antitumor strategies that can reverse immune escape are summarized. |
| format | Article |
| id | doaj-art-75e58e07ab9d4708b427a4488aeb0bad |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-75e58e07ab9d4708b427a4488aeb0bad2025-08-20T01:49:41ZengWileyAdvanced Science2198-38442025-03-011212n/an/a10.1002/advs.202417357Effect of Extracellular Vesicles Derived From Tumor Cells on Immune EvasionXuanfan Liu0Kenneth K.W. To1Qinsong Zeng2Liwu Fu3State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Collaborative Innovation Center for Cancer Medicine Guangdong Esophageal Cancer Institute Sun Yat‐sen University Cancer Center Guangzhou 510060 P. R. ChinaSchool of Pharmacy The Chinese University of Hong Kong Hong Kong 999077 P. R. ChinaDepartment of Urology The First Affiliated Hospital of Sun Yat‐sen University Guangzhou 510080 P. R. ChinaState Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Collaborative Innovation Center for Cancer Medicine Guangdong Esophageal Cancer Institute Sun Yat‐sen University Cancer Center Guangzhou 510060 P. R. ChinaAbstract The crosstalk between immunity and cancer in the regulation of tumor growth is considered a hallmark of cancer. Antitumor immunity refers to the innate and adaptive immune responses that regulate cancer development and proliferation. Tumor immune evasion represents a major hindrance to effective anticancer treatment. Extracellular vesicles (EVs) are nano‐sized and lipid‐bilayer‐enclosed particles that are secreted to the extracellular space by all cell types. They are critically involved in numerous biological functions including intercellular communication. Tumor‐derived extracellular vesicles (TEVs) can transport a variety of cargo to modulate immune cells in the tumor microenvironment (TME). This review provides the latest update about how tumor cells evade immune surveillance by exploiting TEVs. First, the biogenesis of EVs and the cargo‐sorting machinery are discussed. Second, how tumor cells modulate immune cell differentiation, activation, and function via TEVs to evade immune surveillance is illustrated. Last but not least, the novel antitumor strategies that can reverse immune escape are summarized.https://doi.org/10.1002/advs.202417357extracellular vesiclesimmune evasionimmunotherapytargeted therapiestumor microenvironment |
| spellingShingle | Xuanfan Liu Kenneth K.W. To Qinsong Zeng Liwu Fu Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion Advanced Science extracellular vesicles immune evasion immunotherapy targeted therapies tumor microenvironment |
| title | Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion |
| title_full | Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion |
| title_fullStr | Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion |
| title_full_unstemmed | Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion |
| title_short | Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion |
| title_sort | effect of extracellular vesicles derived from tumor cells on immune evasion |
| topic | extracellular vesicles immune evasion immunotherapy targeted therapies tumor microenvironment |
| url | https://doi.org/10.1002/advs.202417357 |
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