CuO-NPs Induce Apoptosis and Functional Impairment in BV2 Cells Through the CSF-1R/PLCγ2/ERK/Nrf2 Pathway

CuO-NPs Induce Apoptosis and Functional Impairment in BV2 Cells Through the CSF-1R/PLCγ2/ERK/Nrf2 Pathway

Copper oxide nanoparticles (CuO-NPs) induce neurological diseases, including neurobehavioral defects and neurodegenerative diseases. Direct evidence indicates that CuO-NPs induce inflammation in the central nervous system and cause severe neurotoxicity. However, the mechanism of CuO-NP-induced damag...

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Bibliographic Details
Main Authors: Linhui Yang, Lina Zhu, Bencheng Lin, Yue Shi, Wenqing Lai, Kang Li, Lei Tian, Zhuge Xi, Huanliang Liu
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Toxics
Subjects:
CuO-NPs
microglia
cell apoptosis
CSF-1R/PLCγ2/ERK/Nrf2 pathway
functional impairment
Online Access:https://www.mdpi.com/2305-6304/13/4/231
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