Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism

Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism

Hypoxia-induced Pyrroline-5-Carboxylate Reductase 1 (PYCR1) is implicated in bladder cancer (BC), but its specific role remains elusive. This study investigated how PYCR1 promotes BC progression through glycolysis, histone H3 Lysine 18 Lactylation (H3K18la), and Solute Carrier Family 6 Member 14 (SL...

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Bibliographic Details
Main Authors: Zhuo Li, Qinghua Jiang, Quan Yang, Yujie Zhou, Jiansong Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Cancer Biology & Therapy
Subjects:
Bladder cancer
PYCR1
glycolysis
lactate
histone lactylation
H3K18la
Online Access:https://www.tandfonline.com/doi/10.1080/15384047.2025.2546219
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