Irreversible Electroporation Ablation for Atrial Fibrillation: Status and Challenges
Abstract. Pulsed electric field (PEF) is a novel energy source by which high-voltage electric pulses are used to create irreversible electroporation. PEF is non-thermal and highly tissue-dependent in which specific targeting of the atrial myocardium is achieved and sparing of adjacent tissues is fea...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2022-03-01
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| Series: | Cardiology Discovery |
| Online Access: | http://journals.lww.com/10.1097/CD9.0000000000000045 |
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| _version_ | 1850265779181715456 |
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| author | Fei Xie Yonggang Chen Xinhua Chen Zhihong Zhao Tianyu Xu Xiaoxia Fu |
| author_facet | Fei Xie Yonggang Chen Xinhua Chen Zhihong Zhao Tianyu Xu Xiaoxia Fu |
| author_sort | Fei Xie |
| collection | DOAJ |
| description | Abstract. Pulsed electric field (PEF) is a novel energy source by which high-voltage electric pulses are used to create irreversible electroporation. PEF is non-thermal and highly tissue-dependent in which specific targeting of the atrial myocardium is achieved and sparing of adjacent tissues is feasible, theoretically increasing the safety of the procedure, which could potentially break the trade-off between effective lesions and collateral damage and substantially improve risk-benefit ratios in atrial fibrillation (AF) ablation. Although recently published trials have shown a clear effect of AF ablation, large-scale clinical trials are lacking. Current clinical evidence has demonstrated significant efficacy in achieving durable pulmonary vein isolation without ablation-related adverse events. However, their putative benefits regarding efficacy, efficiency, and safety remain to be proven in randomized controlled trials. |
| format | Article |
| id | doaj-art-75cb483abffa4bae950bcd248c94f215 |
| institution | OA Journals |
| issn | 2096-952X 2693-8499 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Cardiology Discovery |
| spelling | doaj-art-75cb483abffa4bae950bcd248c94f2152025-08-20T01:54:19ZengWolters Kluwer Health/LWWCardiology Discovery2096-952X2693-84992022-03-0121415010.1097/CD9.0000000000000045202203000-00006Irreversible Electroporation Ablation for Atrial Fibrillation: Status and ChallengesFei XieYonggang ChenXinhua ChenZhihong ZhaoTianyu XuXiaoxia FuAbstract. Pulsed electric field (PEF) is a novel energy source by which high-voltage electric pulses are used to create irreversible electroporation. PEF is non-thermal and highly tissue-dependent in which specific targeting of the atrial myocardium is achieved and sparing of adjacent tissues is feasible, theoretically increasing the safety of the procedure, which could potentially break the trade-off between effective lesions and collateral damage and substantially improve risk-benefit ratios in atrial fibrillation (AF) ablation. Although recently published trials have shown a clear effect of AF ablation, large-scale clinical trials are lacking. Current clinical evidence has demonstrated significant efficacy in achieving durable pulmonary vein isolation without ablation-related adverse events. However, their putative benefits regarding efficacy, efficiency, and safety remain to be proven in randomized controlled trials.http://journals.lww.com/10.1097/CD9.0000000000000045 |
| spellingShingle | Fei Xie Yonggang Chen Xinhua Chen Zhihong Zhao Tianyu Xu Xiaoxia Fu Irreversible Electroporation Ablation for Atrial Fibrillation: Status and Challenges Cardiology Discovery |
| title | Irreversible Electroporation Ablation for Atrial Fibrillation: Status and Challenges |
| title_full | Irreversible Electroporation Ablation for Atrial Fibrillation: Status and Challenges |
| title_fullStr | Irreversible Electroporation Ablation for Atrial Fibrillation: Status and Challenges |
| title_full_unstemmed | Irreversible Electroporation Ablation for Atrial Fibrillation: Status and Challenges |
| title_short | Irreversible Electroporation Ablation for Atrial Fibrillation: Status and Challenges |
| title_sort | irreversible electroporation ablation for atrial fibrillation status and challenges |
| url | http://journals.lww.com/10.1097/CD9.0000000000000045 |
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