Relationship between parathyroid hormone and left ventricular hypertrophy in patients undergoing maintenance hemodialysis
Objective To investigate the relationship between parathyroid hormone(PTH) and left ventricular hypertrophy(LVH) in patients undergoing maintenance hemodialysis(MHD).Methods Fifty MHD patients from the Dialysis Center of Tongji Hospital of Tongji University were divided into L-PTH group(PTH <300...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2016-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57918305&Fpath=home&index=0 |
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| Summary: | Objective To investigate the relationship between parathyroid hormone(PTH) and left ventricular hypertrophy(LVH) in patients undergoing maintenance hemodialysis(MHD).Methods Fifty MHD patients from the Dialysis Center of Tongji Hospital of Tongji University were divided into L-PTH group(PTH <300 ng/L) and H-PTH group(PTH >300 ng/L).All cases underwent echocardiography examination and clinical biochemical tests.The relationship between echocardiography structure and the incidence of LVH was analyzed.Results There were no significant differences in the age,gender,blood pressure,BNP,hemoglobin(Hb),calcium and albumin between the two groups.The dialysis time and phosphorus in H-PTH group were significantly increased as compared with those in the L-PTH group[(8.66 ± 4.91) years vs.(5.4 ± 5.73) years;(1.81 ± 0.37)mmol/L vs.(1.51 ± 0.32) mmol/L,P<0.05].Left ventricular end-diastolic diameter(LVEDd),left ventricular end-systolic diameter(LVEDs),interventricular septal thickness(IVST) and left ventricular mass index(LVMI) were significantly higher in the H-PTH group than those in the L-PTH group[(49.56±4.59)mm vs.(45.84±5.65)mm,(32.44±4.26)mm vs.(29.6±5.00)mm;(11.12±1.45)mm vs.(10.16±1.41)mm;(144.29±31.82)g/m~3 vs.(122.83±38.34)g/m~3,P<0.05].The left atrial diameter(LAD),left ventricular posterior wall thickness(LVPWT) and ejection fraction(EF) had no significant difference[(43.96±3.98)mm vs.(42.52 ± 5.86)mm;(9.56±1.58)mm vs.(9.08±1.29)mm;(63.16±6.97)vs.(65.72±6.67)%,P>0.05].The incidence of LVH in the H-PTH group was significantly higher than that in the L-PTH group(72%vs.40%,P<0.05).Correlation analysis showed that PTH levels were positively correlated with LVMI,LVEDd,LVEDs and IVST(r=0.325,0.330,0.348,and 0.310 respectively,P<0.05),but PTH levels were not significantly correlated with LAD,LVPWT and EF(r=0.088,0.115 and-0.210 respectively,P>0.05).Conclusions Increased PTH level is an important factor leading to LVH in MHD patients. |
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| ISSN: | 1671-2390 |