The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis
Yersinia enterocolitica O:3 is mentioned among the most common arthritogenic pathogens. Bacterial components (including lipopolysaccharide (LPS)) may persist in the joint after eradication of infection. Having an adjuvant activity, LPS may enhance production of anticollagen antibodies, involved in t...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/7439506 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560320008159232 |
|---|---|
| author | Katarzyna Kasperkiewicz Anna S. Świerzko Marta Przybyła Janusz Szemraj Jarosław Barski Mikael Skurnik Andrzej Kałużyński Maciej Cedzyński |
| author_facet | Katarzyna Kasperkiewicz Anna S. Świerzko Marta Przybyła Janusz Szemraj Jarosław Barski Mikael Skurnik Andrzej Kałużyński Maciej Cedzyński |
| author_sort | Katarzyna Kasperkiewicz |
| collection | DOAJ |
| description | Yersinia enterocolitica O:3 is mentioned among the most common arthritogenic pathogens. Bacterial components (including lipopolysaccharide (LPS)) may persist in the joint after eradication of infection. Having an adjuvant activity, LPS may enhance production of anticollagen antibodies, involved in the pathogenesis of rheumatoid arthritis. Furthermore, its ability to activate complement contributes to the inflammation. The aim of this work was to investigate whether Yersinia LPS (coinjected with collagen) is associated with arthritis progression or other pathological effects and to elucidate the mechanism of this association. It was demonstrated that murine mannose-binding lectin C (MBL-C) recognizes the inner core heptoses of the Rd1 chemotype LPS of Yersinia. In addition, the Rd1 LPS activates the MBL-associated serine protease 1 (MASP-1) stronger than the S and Ra chemotype LPS and comparable to Klebsiella pneumoniae O:3 LPS. However, in contrast to the latter, Yersinia Rd1 LPS was associated neither with the adjuvancity nor with the enhancement of pathological changes in animal paws/impairment of motility. On the other hand, it seemed to be more hepatotoxic when compared with the other tested endotoxins, while the enlargement of inguinal lymph nodes and drop in hepatic MBL-C expression (at the mRNA level) were independent of LPS chemotype. Our data did not suggest no greater impact Y. enterocolitica O:3 on the development or severity of arthropathy related to anticollagen antibody-induced arthritis in mice, although its interaction with MBL-C and subsequent complement activation may contribute to some adverse effects. |
| format | Article |
| id | doaj-art-75c0d5ddab9a46849a911979f7fab4e3 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-75c0d5ddab9a46849a911979f7fab4e32025-02-03T01:27:56ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/74395067439506The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced ArthritisKatarzyna Kasperkiewicz0Anna S. Świerzko1Marta Przybyła2Janusz Szemraj3Jarosław Barski4Mikael Skurnik5Andrzej Kałużyński6Maciej Cedzyński7University of Silesia in Katowice, Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, Jagiellonska 28, 40-032 Katowice, PolandLaboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, PolandDepartment for Experimental Medicine, Medical University of Silesia, Medyków 4, 40-752 Katowice, PolandDepartment of Medical Biochemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, PolandDepartment for Experimental Medicine, Medical University of Silesia, Medyków 4, 40-752 Katowice, PolandDepartment of Bacteriology and Immunology, Medicum, Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki, FinlandDepartment of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Rzgowska 281/289, 93-338 Lodz, PolandLaboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, PolandYersinia enterocolitica O:3 is mentioned among the most common arthritogenic pathogens. Bacterial components (including lipopolysaccharide (LPS)) may persist in the joint after eradication of infection. Having an adjuvant activity, LPS may enhance production of anticollagen antibodies, involved in the pathogenesis of rheumatoid arthritis. Furthermore, its ability to activate complement contributes to the inflammation. The aim of this work was to investigate whether Yersinia LPS (coinjected with collagen) is associated with arthritis progression or other pathological effects and to elucidate the mechanism of this association. It was demonstrated that murine mannose-binding lectin C (MBL-C) recognizes the inner core heptoses of the Rd1 chemotype LPS of Yersinia. In addition, the Rd1 LPS activates the MBL-associated serine protease 1 (MASP-1) stronger than the S and Ra chemotype LPS and comparable to Klebsiella pneumoniae O:3 LPS. However, in contrast to the latter, Yersinia Rd1 LPS was associated neither with the adjuvancity nor with the enhancement of pathological changes in animal paws/impairment of motility. On the other hand, it seemed to be more hepatotoxic when compared with the other tested endotoxins, while the enlargement of inguinal lymph nodes and drop in hepatic MBL-C expression (at the mRNA level) were independent of LPS chemotype. Our data did not suggest no greater impact Y. enterocolitica O:3 on the development or severity of arthropathy related to anticollagen antibody-induced arthritis in mice, although its interaction with MBL-C and subsequent complement activation may contribute to some adverse effects.http://dx.doi.org/10.1155/2020/7439506 |
| spellingShingle | Katarzyna Kasperkiewicz Anna S. Świerzko Marta Przybyła Janusz Szemraj Jarosław Barski Mikael Skurnik Andrzej Kałużyński Maciej Cedzyński The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis Journal of Immunology Research |
| title | The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis |
| title_full | The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis |
| title_fullStr | The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis |
| title_full_unstemmed | The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis |
| title_short | The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis |
| title_sort | role of yersinia enterocolitica o 3 lipopolysaccharide in collagen induced arthritis |
| url | http://dx.doi.org/10.1155/2020/7439506 |
| work_keys_str_mv | AT katarzynakasperkiewicz theroleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT annasswierzko theroleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT martaprzybyła theroleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT januszszemraj theroleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT jarosławbarski theroleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT mikaelskurnik theroleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT andrzejkałuzynski theroleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT maciejcedzynski theroleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT katarzynakasperkiewicz roleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT annasswierzko roleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT martaprzybyła roleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT januszszemraj roleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT jarosławbarski roleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT mikaelskurnik roleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT andrzejkałuzynski roleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis AT maciejcedzynski roleofyersiniaenterocoliticao3lipopolysaccharideincollageninducedarthritis |