A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, Ethiopia
Abstract Objective This study aimed to assess the prevalence of intestinal parasitic infections among pregnant women in the third trimester who received prior presumptive deworming in 12 health centers in the Amhara region, Ethiopia. This sub-study was part of the parent Enhancing Nutrition and Ante...
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2025-06-01
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| Online Access: | https://doi.org/10.1186/s13104-025-07309-w |
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| author | Kalkidan Yibeltal Firehiwot Workneh Nebiyou Fasil Estifanos Baye Yunhee Kang Workagegnhu Tarekegn Kidane Sitota Tsegaye Yoseph Yemane Berhane Bethlehem Haymanot Ingrid E. Olson Mulatu Melese Derebe Rose L. Molina Blair J. Wylie Grace J. Chan Parul Christian Alemayehu Worku Anne CC Lee Yemane Berhane |
| author_facet | Kalkidan Yibeltal Firehiwot Workneh Nebiyou Fasil Estifanos Baye Yunhee Kang Workagegnhu Tarekegn Kidane Sitota Tsegaye Yoseph Yemane Berhane Bethlehem Haymanot Ingrid E. Olson Mulatu Melese Derebe Rose L. Molina Blair J. Wylie Grace J. Chan Parul Christian Alemayehu Worku Anne CC Lee Yemane Berhane |
| author_sort | Kalkidan Yibeltal |
| collection | DOAJ |
| description | Abstract Objective This study aimed to assess the prevalence of intestinal parasitic infections among pregnant women in the third trimester who received prior presumptive deworming in 12 health centers in the Amhara region, Ethiopia. This sub-study was part of the parent Enhancing Nutrition and Antenatal Infection Treatment (ENAT) study; a randomized clinical effectiveness study conducted to determine the effectiveness of packages of antenatal interventions to enhance maternal nutrition and infection management on birth outcomes. Results Three hundred fifty women provided a stool sample in their 3rd trimester for screening using wet mount microscopy. All women had previously received 500 mg of presumptive mebendazole in the 2nd trimester. One in three women (109/350, 31.0%) were found to have a parasitic stool infection after prior deworming and 15% of women reported gastrointestinal symptoms. The most common infections were Giardia lamblia (n = 43, 37.4%), Entamoeba histolytica (n = 40, 34.8%), and Hookworm (n = 25, 21.7%). Six mothers had co-infections with at least two parasites with trophozoites of Giardia lamblia and Entamoeba histolytica co-infection being dominant. |
| format | Article |
| id | doaj-art-75b7855babcd4eab87d0f65debcc2b0e |
| institution | DOAJ |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
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| series | BMC Research Notes |
| spelling | doaj-art-75b7855babcd4eab87d0f65debcc2b0e2025-08-20T03:10:27ZengBMCBMC Research Notes1756-05002025-06-011811510.1186/s13104-025-07309-wA single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, EthiopiaKalkidan Yibeltal0Firehiwot Workneh1Nebiyou Fasil2Estifanos Baye3Yunhee Kang4Workagegnhu Tarekegn Kidane5Sitota Tsegaye6Yoseph Yemane Berhane7Bethlehem Haymanot8Ingrid E. Olson9Mulatu Melese Derebe10Rose L. Molina11Blair J. Wylie12Grace J. Chan13Parul Christian14Alemayehu Worku15Anne CC Lee16Yemane Berhane17Department of Reproductive Health and Population, Addis Continental Institute of Public HealthDepartment of Epidemiology and Biostatistics, Addis Continental Institute of Public HealthDepartment of Global Health and Health Policy, Addis Continental Institute of Public HealthDepartment of Pediatrics, Brigham and Women’s HospitalCenter for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public HealthDepartment of Nutrition and Behavioral Science, Addis Continental Institute of Public HealthDepartment of Nutrition and Behavioral Science, Addis Continental Institute of Public HealthDepartment of Epidemiology and Biostatistics, Addis Continental Institute of Public HealthAddis Continental Institute of Public HealthDepartment of Pediatrics, Brigham and Women’s HospitalAmhara Public Health InstituteHarvard Medical SchoolDepartment of Obstetrics and Gynecology, Columbia University Irving Medical CenterHarvard Medical SchoolCenter for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public HealthDepartment of Epidemiology and Biostatistics, Addis Continental Institute of Public HealthDepartment of Pediatrics, Brigham and Women’s HospitalDepartment of Epidemiology and Biostatistics, Addis Continental Institute of Public HealthAbstract Objective This study aimed to assess the prevalence of intestinal parasitic infections among pregnant women in the third trimester who received prior presumptive deworming in 12 health centers in the Amhara region, Ethiopia. This sub-study was part of the parent Enhancing Nutrition and Antenatal Infection Treatment (ENAT) study; a randomized clinical effectiveness study conducted to determine the effectiveness of packages of antenatal interventions to enhance maternal nutrition and infection management on birth outcomes. Results Three hundred fifty women provided a stool sample in their 3rd trimester for screening using wet mount microscopy. All women had previously received 500 mg of presumptive mebendazole in the 2nd trimester. One in three women (109/350, 31.0%) were found to have a parasitic stool infection after prior deworming and 15% of women reported gastrointestinal symptoms. The most common infections were Giardia lamblia (n = 43, 37.4%), Entamoeba histolytica (n = 40, 34.8%), and Hookworm (n = 25, 21.7%). Six mothers had co-infections with at least two parasites with trophozoites of Giardia lamblia and Entamoeba histolytica co-infection being dominant.https://doi.org/10.1186/s13104-025-07309-wDewormingIntestinal parasiteInfectionPregnancyEthiopia |
| spellingShingle | Kalkidan Yibeltal Firehiwot Workneh Nebiyou Fasil Estifanos Baye Yunhee Kang Workagegnhu Tarekegn Kidane Sitota Tsegaye Yoseph Yemane Berhane Bethlehem Haymanot Ingrid E. Olson Mulatu Melese Derebe Rose L. Molina Blair J. Wylie Grace J. Chan Parul Christian Alemayehu Worku Anne CC Lee Yemane Berhane A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, Ethiopia BMC Research Notes Deworming Intestinal parasite Infection Pregnancy Ethiopia |
| title | A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, Ethiopia |
| title_full | A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, Ethiopia |
| title_fullStr | A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, Ethiopia |
| title_full_unstemmed | A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, Ethiopia |
| title_short | A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, Ethiopia |
| title_sort | single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural amhara ethiopia |
| topic | Deworming Intestinal parasite Infection Pregnancy Ethiopia |
| url | https://doi.org/10.1186/s13104-025-07309-w |
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