Studying Intracellular pH of Bacteria with Fluorescent Tools
This perspective discusses the relevance of studying the intracellular pH of pathogenic bacteria. Acidic environments trigger phenotype switches, increasing stress tolerance and antibiotic persistence – key challenges in treating bacterial infections. Understanding these phenotypic adaptations under...
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2025-04-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://www.chimia.ch/chimia/article/view/7929 |
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| _version_ | 1850042866235080704 |
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| author | Dorothea Kossmann |
| author_facet | Dorothea Kossmann |
| author_sort | Dorothea Kossmann |
| collection | DOAJ |
| description | This perspective discusses the relevance of studying the intracellular pH of pathogenic bacteria. Acidic environments trigger phenotype switches, increasing stress tolerance and antibiotic persistence – key challenges in treating bacterial infections. Understanding these phenotypic adaptations under clinically relevant stress conditions is important for elucidating bacterial survival mechanisms. Here, we discuss fluorescent tools to monitor pH homeostasis in bacterial cells and how advances in this field could shed light on pathogen resilience to antibiotics and human immune responses.
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| format | Article |
| id | doaj-art-75b50d4c0e804af1bbe34202fdca3cb5 |
| institution | DOAJ |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 2025-04-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-75b50d4c0e804af1bbe34202fdca3cb52025-08-20T02:55:24ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242025-04-0179410.2533/chimia.2025.245Studying Intracellular pH of Bacteria with Fluorescent ToolsDorothea Kossmann0Department of Chemistry, University of Zurich, CH-8057 ZurichThis perspective discusses the relevance of studying the intracellular pH of pathogenic bacteria. Acidic environments trigger phenotype switches, increasing stress tolerance and antibiotic persistence – key challenges in treating bacterial infections. Understanding these phenotypic adaptations under clinically relevant stress conditions is important for elucidating bacterial survival mechanisms. Here, we discuss fluorescent tools to monitor pH homeostasis in bacterial cells and how advances in this field could shed light on pathogen resilience to antibiotics and human immune responses. https://www.chimia.ch/chimia/article/view/7929BacteriaFluorescent toolsPersistencePhenotype switchpH sensing |
| spellingShingle | Dorothea Kossmann Studying Intracellular pH of Bacteria with Fluorescent Tools CHIMIA Bacteria Fluorescent tools Persistence Phenotype switch pH sensing |
| title | Studying Intracellular pH of Bacteria with Fluorescent Tools |
| title_full | Studying Intracellular pH of Bacteria with Fluorescent Tools |
| title_fullStr | Studying Intracellular pH of Bacteria with Fluorescent Tools |
| title_full_unstemmed | Studying Intracellular pH of Bacteria with Fluorescent Tools |
| title_short | Studying Intracellular pH of Bacteria with Fluorescent Tools |
| title_sort | studying intracellular ph of bacteria with fluorescent tools |
| topic | Bacteria Fluorescent tools Persistence Phenotype switch pH sensing |
| url | https://www.chimia.ch/chimia/article/view/7929 |
| work_keys_str_mv | AT dorotheakossmann studyingintracellularphofbacteriawithfluorescenttools |