The influence of the gut microbiota on B cells in autoimmune diseases
Abstract Mounting evidence shows that gut microbiota communities and the human immune system coexist and influence each other, and there are a number of reports of a correlation between specific changes in gut microbiota and the occurrence of autoimmune diseases. B lymphocytes play a central role in...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Molecular Medicine |
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| Online Access: | https://doi.org/10.1186/s10020-025-01195-5 |
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| author | Lun He Xin Li Shan Jiang Yanhua Ou Shanshan Wang Na Shi Zhongshan Yang Jia-li Yuan Gregg Silverman Haitao Niu |
| author_facet | Lun He Xin Li Shan Jiang Yanhua Ou Shanshan Wang Na Shi Zhongshan Yang Jia-li Yuan Gregg Silverman Haitao Niu |
| author_sort | Lun He |
| collection | DOAJ |
| description | Abstract Mounting evidence shows that gut microbiota communities and the human immune system coexist and influence each other, and there are a number of reports of a correlation between specific changes in gut microbiota and the occurrence of autoimmune diseases. B lymphocytes play a central role in the regulation of both gut microbiota communities and in autoimmune diseases. Here, we summarize evidence of the influence of gut microbiota-B cell pathways on autoimmune diseases and how B cells regulate microorganisms, which provides mechanistic insights with relevance for identification of potential therapeutic targets and related fields. |
| format | Article |
| id | doaj-art-75b4e60308484170b0c7cfbc09d432fc |
| institution | OA Journals |
| issn | 1528-3658 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj-art-75b4e60308484170b0c7cfbc09d432fc2025-08-20T02:20:06ZengBMCMolecular Medicine1528-36582025-04-0131111610.1186/s10020-025-01195-5The influence of the gut microbiota on B cells in autoimmune diseasesLun He0Xin Li1Shan Jiang2Yanhua Ou3Shanshan Wang4Na Shi5Zhongshan Yang6Jia-li Yuan7Gregg Silverman8Haitao Niu9Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education; Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, School of Medicine, Jinan UniversityKey Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education; Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, School of Medicine, Jinan UniversityKey Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education; Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, School of Medicine, Jinan UniversityKey Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education; Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, School of Medicine, Jinan UniversityKey Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education; Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, School of Medicine, Jinan UniversityKey Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education; Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, School of Medicine, Jinan UniversityYunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, Yunnan University of Chinese MedicineYunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, Yunnan University of Chinese MedicineDivision of Rheumatology, New York University School of MedicineKey Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education; Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, School of Medicine, Jinan UniversityAbstract Mounting evidence shows that gut microbiota communities and the human immune system coexist and influence each other, and there are a number of reports of a correlation between specific changes in gut microbiota and the occurrence of autoimmune diseases. B lymphocytes play a central role in the regulation of both gut microbiota communities and in autoimmune diseases. Here, we summarize evidence of the influence of gut microbiota-B cell pathways on autoimmune diseases and how B cells regulate microorganisms, which provides mechanistic insights with relevance for identification of potential therapeutic targets and related fields.https://doi.org/10.1186/s10020-025-01195-5Gut microbiotaB lymphocytesAutoantibodiesIgABregsGerminal centers |
| spellingShingle | Lun He Xin Li Shan Jiang Yanhua Ou Shanshan Wang Na Shi Zhongshan Yang Jia-li Yuan Gregg Silverman Haitao Niu The influence of the gut microbiota on B cells in autoimmune diseases Molecular Medicine Gut microbiota B lymphocytes Autoantibodies IgA Bregs Germinal centers |
| title | The influence of the gut microbiota on B cells in autoimmune diseases |
| title_full | The influence of the gut microbiota on B cells in autoimmune diseases |
| title_fullStr | The influence of the gut microbiota on B cells in autoimmune diseases |
| title_full_unstemmed | The influence of the gut microbiota on B cells in autoimmune diseases |
| title_short | The influence of the gut microbiota on B cells in autoimmune diseases |
| title_sort | influence of the gut microbiota on b cells in autoimmune diseases |
| topic | Gut microbiota B lymphocytes Autoantibodies IgA Bregs Germinal centers |
| url | https://doi.org/10.1186/s10020-025-01195-5 |
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