Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study
Abstract Effective cancer treatment is currently the number one challenge to human health. To date, several treatment methods have been introduced for cancer cell targeting. Among the proposed new methods for attacking cancer cells, nanotechnology has attracted much attention. Hence, various nanocar...
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/nbt2.12073 |
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| author | Neda Rostami Reza Davarnejad |
| author_facet | Neda Rostami Reza Davarnejad |
| author_sort | Neda Rostami |
| collection | DOAJ |
| description | Abstract Effective cancer treatment is currently the number one challenge to human health. To date, several treatment methods have been introduced for cancer cell targeting. Among the proposed new methods for attacking cancer cells, nanotechnology has attracted much attention. Hence, various nanocarriers have been developed for targeted delivery of available drugs and improve their effectiveness against malignant cells. The PLA–PEG functionalised with folic acid (PLA–PEG‐FA) is one of the nanocarriers with a limited range of applications for targeting cancer cells. In this investigation, different types of in‐silico methods such as molecular docking approach, molecular dynamics simulation and free energy calculations are employed to characterise the carriers studied. The effectiveness of PLA–PEG‐FA and PLA–PEG in delivering Letrozole as an aromatase inhibitor in cancer cells is examined. It is found that in the presence of folic acid, the stability and cell membrane permeability of nanomicelle are increased. Therefore, PLA–PEG‐FA can be considered as a versatile carrier that can increase the effectiveness of aromatase inhibitors (such as Letrozole) and reduce their side effects. |
| format | Article |
| id | doaj-art-75b48669c02d4b7d88db3a67257016b9 |
| institution | Kabale University |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj-art-75b48669c02d4b7d88db3a67257016b92025-08-20T03:35:32ZengWileyIET Nanobiotechnology1751-87411751-875X2022-06-0116410311410.1049/nbt2.12073Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics studyNeda Rostami0Reza Davarnejad1Department of Chemical Engineering, Faculty of Engineering Arak University Arak IranDepartment of Chemical Engineering, Faculty of Engineering Arak University Arak IranAbstract Effective cancer treatment is currently the number one challenge to human health. To date, several treatment methods have been introduced for cancer cell targeting. Among the proposed new methods for attacking cancer cells, nanotechnology has attracted much attention. Hence, various nanocarriers have been developed for targeted delivery of available drugs and improve their effectiveness against malignant cells. The PLA–PEG functionalised with folic acid (PLA–PEG‐FA) is one of the nanocarriers with a limited range of applications for targeting cancer cells. In this investigation, different types of in‐silico methods such as molecular docking approach, molecular dynamics simulation and free energy calculations are employed to characterise the carriers studied. The effectiveness of PLA–PEG‐FA and PLA–PEG in delivering Letrozole as an aromatase inhibitor in cancer cells is examined. It is found that in the presence of folic acid, the stability and cell membrane permeability of nanomicelle are increased. Therefore, PLA–PEG‐FA can be considered as a versatile carrier that can increase the effectiveness of aromatase inhibitors (such as Letrozole) and reduce their side effects.https://doi.org/10.1049/nbt2.12073cancercell membraneLetrozolemolecular dynamicsnanomicelletargeted delivery |
| spellingShingle | Neda Rostami Reza Davarnejad Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study IET Nanobiotechnology cancer cell membrane Letrozole molecular dynamics nanomicelle targeted delivery |
| title | Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study |
| title_full | Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study |
| title_fullStr | Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study |
| title_full_unstemmed | Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study |
| title_short | Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study |
| title_sort | characterization of folic acid functionalized pla peg nanomicelle to deliver letrozole a nanoinformatics study |
| topic | cancer cell membrane Letrozole molecular dynamics nanomicelle targeted delivery |
| url | https://doi.org/10.1049/nbt2.12073 |
| work_keys_str_mv | AT nedarostami characterizationoffolicacidfunctionalizedplapegnanomicelletodeliverletrozoleananoinformaticsstudy AT rezadavarnejad characterizationoffolicacidfunctionalizedplapegnanomicelletodeliverletrozoleananoinformaticsstudy |