THE MORPHOLOGICAL SUBSTRATE AND IMMUNOHYSTOARCHITECTURAL PATTERNS IN NODULAR LYMPHOCYTE PREDOMINANT HODGKIN LYMPHOMA
The aim of the study is to compare the tumour growth pattern with immunohystoarchitectural patterns in patients with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) in the debut of the disease. Material and methods. The diagnosis of NLPHL in the debut of the disease was established in 60 pat...
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Russian Academy of Sciences, Siberian Branch Publishing House
2019-03-01
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| Series: | Сибирский научный медицинский журнал |
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| author | I. A. Shupletsova A. M. Kovrigina T. N. Moiseeva E. I. Dorokhina |
| author_facet | I. A. Shupletsova A. M. Kovrigina T. N. Moiseeva E. I. Dorokhina |
| author_sort | I. A. Shupletsova |
| collection | DOAJ |
| description | The aim of the study is to compare the tumour growth pattern with immunohystoarchitectural patterns in patients with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) in the debut of the disease. Material and methods. The diagnosis of NLPHL in the debut of the disease was established in 60 patients (male/female ratio is 3.6:1, median age – 37 (range 17–68)) using morphology an expanded immunohistochemical study. The tumor growth pattern was determined by morphological study and immunohistochemical patterns (WHO 2017) – using antibodies to CD20 and clinical stages (Ann Arbor). Results and discussion. All patients were divided into 3 immunohystoarchitectural patterns (subject to immunohystoarchitectonics in reaction with antibodies to CD20): A – LP cells are located within B cell nodules; B – LP cells are located intra- and extranodular with the preservation of B cell nodules or in the presence of a border of B-lymphocytes; C – predominant (> 50 % of section area) diffuse or large-focal discrete arrangement of LP cells without the presence of a B cell border. Concerning to the immunohystoarchitectural patterns, all the patients were divided into three groups: I (immunohistochemical pattern A – 17 cases, 28 %, stage – I–II 82 %, stage III – 18 %, nodular growth – 100 %), II (immunohistochemical pattern B – 30 cases, 50 %, stage I–II – 40 %, stage III–IV – 60 %, nodular growth – 3 %, nodular growth with a significant number of extranodular LP cells – 43 %, nodular-diffuse growth – 53 % cases), III (immunohistochemical pattern C – 12 patients, 20 %; II stage – 8 %, tumor cell-rich case, stage III–IV – 92 %; nodular-diffuse growth – 75 % cases, mainly diffuse growth – 25 % cases), 1 case with transformation in DLBCL (2 %, IV stage). Conclusions. NLPHL is characterized by variable morphological immunohistochemical patterns among which we’ve revealed 4 morphological variants and 3 immunohistochemical patterns considered as sign of immunohistochemical transformation within the continuum of the same entity of NLHLP. The immunohistochemical patterns are not always a predictor of the clinical course of the disease. «Tumor cell-rich» cases require further detailed research. |
| format | Article |
| id | doaj-art-75b0593dc6a34bd09084667f3a4e6eac |
| institution | Kabale University |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| publishDate | 2019-03-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
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| series | Сибирский научный медицинский журнал |
| spelling | doaj-art-75b0593dc6a34bd09084667f3a4e6eac2025-08-20T03:50:44ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202019-03-01391273310.15372/SSMJ20190104100THE MORPHOLOGICAL SUBSTRATE AND IMMUNOHYSTOARCHITECTURAL PATTERNS IN NODULAR LYMPHOCYTE PREDOMINANT HODGKIN LYMPHOMAI. A. Shupletsova0A. M. Kovrigina1T. N. Moiseeva2E. I. Dorokhina3National Research Center for Hematology of Minzdrav of RussiaNational Research Center for Hematology of Minzdrav of RussiaNational Research Center for Hematology of Minzdrav of RussiaNational Research Center for Hematology of Minzdrav of RussiaThe aim of the study is to compare the tumour growth pattern with immunohystoarchitectural patterns in patients with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) in the debut of the disease. Material and methods. The diagnosis of NLPHL in the debut of the disease was established in 60 patients (male/female ratio is 3.6:1, median age – 37 (range 17–68)) using morphology an expanded immunohistochemical study. The tumor growth pattern was determined by morphological study and immunohistochemical patterns (WHO 2017) – using antibodies to CD20 and clinical stages (Ann Arbor). Results and discussion. All patients were divided into 3 immunohystoarchitectural patterns (subject to immunohystoarchitectonics in reaction with antibodies to CD20): A – LP cells are located within B cell nodules; B – LP cells are located intra- and extranodular with the preservation of B cell nodules or in the presence of a border of B-lymphocytes; C – predominant (> 50 % of section area) diffuse or large-focal discrete arrangement of LP cells without the presence of a B cell border. Concerning to the immunohystoarchitectural patterns, all the patients were divided into three groups: I (immunohistochemical pattern A – 17 cases, 28 %, stage – I–II 82 %, stage III – 18 %, nodular growth – 100 %), II (immunohistochemical pattern B – 30 cases, 50 %, stage I–II – 40 %, stage III–IV – 60 %, nodular growth – 3 %, nodular growth with a significant number of extranodular LP cells – 43 %, nodular-diffuse growth – 53 % cases), III (immunohistochemical pattern C – 12 patients, 20 %; II stage – 8 %, tumor cell-rich case, stage III–IV – 92 %; nodular-diffuse growth – 75 % cases, mainly diffuse growth – 25 % cases), 1 case with transformation in DLBCL (2 %, IV stage). Conclusions. NLPHL is characterized by variable morphological immunohistochemical patterns among which we’ve revealed 4 morphological variants and 3 immunohistochemical patterns considered as sign of immunohistochemical transformation within the continuum of the same entity of NLHLP. The immunohistochemical patterns are not always a predictor of the clinical course of the disease. «Tumor cell-rich» cases require further detailed research.https://sibmed.elpub.ru/jour/article/view/100нодулярная лимфома ходжкина с лимфоидным преобладаниемморфологияиммунофенотипиммуногистоархитектоника |
| spellingShingle | I. A. Shupletsova A. M. Kovrigina T. N. Moiseeva E. I. Dorokhina THE MORPHOLOGICAL SUBSTRATE AND IMMUNOHYSTOARCHITECTURAL PATTERNS IN NODULAR LYMPHOCYTE PREDOMINANT HODGKIN LYMPHOMA Сибирский научный медицинский журнал нодулярная лимфома ходжкина с лимфоидным преобладанием морфология иммунофенотип иммуногистоархитектоника |
| title | THE MORPHOLOGICAL SUBSTRATE AND IMMUNOHYSTOARCHITECTURAL PATTERNS IN NODULAR LYMPHOCYTE PREDOMINANT HODGKIN LYMPHOMA |
| title_full | THE MORPHOLOGICAL SUBSTRATE AND IMMUNOHYSTOARCHITECTURAL PATTERNS IN NODULAR LYMPHOCYTE PREDOMINANT HODGKIN LYMPHOMA |
| title_fullStr | THE MORPHOLOGICAL SUBSTRATE AND IMMUNOHYSTOARCHITECTURAL PATTERNS IN NODULAR LYMPHOCYTE PREDOMINANT HODGKIN LYMPHOMA |
| title_full_unstemmed | THE MORPHOLOGICAL SUBSTRATE AND IMMUNOHYSTOARCHITECTURAL PATTERNS IN NODULAR LYMPHOCYTE PREDOMINANT HODGKIN LYMPHOMA |
| title_short | THE MORPHOLOGICAL SUBSTRATE AND IMMUNOHYSTOARCHITECTURAL PATTERNS IN NODULAR LYMPHOCYTE PREDOMINANT HODGKIN LYMPHOMA |
| title_sort | morphological substrate and immunohystoarchitectural patterns in nodular lymphocyte predominant hodgkin lymphoma |
| topic | нодулярная лимфома ходжкина с лимфоидным преобладанием морфология иммунофенотип иммуногистоархитектоника |
| url | https://sibmed.elpub.ru/jour/article/view/100 |
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