HPLC-UV method development and validation for anticancer drug sorafenib and the co-prescribed drug dexamethasone: application to pharmacokinetic evaluation of sorafenib nanoformulations

HPLC-UV method development and validation for anticancer drug sorafenib and the co-prescribed drug dexamethasone: application to pharmacokinetic evaluation of sorafenib nanoformulations

Sorafenib is used to treat advanced renal cell carcinoma. A high-performance liquid chromatography (HPLC) method was developed for the simultaneous determination of sorafenib with a commonly co-prescribed drug, dexamethasone, using meloxicam as an internal standard. The separation was achieved with...

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Bibliographic Details
Main Authors: Abdul Mateen, Abad Khan, Ismail Khan, Saifullah Khan Khalil, Lateef Ahmad, Muhammad Junaid, Saqib Jehan, Muhammad Sohail Anwar, Muhammad Faheem, Abdul Salam
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
HPLC
nanoformulation
sorafenib
dexamethasone
spiked plasma
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1442762/full
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