Dyarrheal Syndrome in a Patient Co-Infected with Leishmania infantum and Schistosoma mansoni
This case report describes an atypical clinical presentation of visceral leishmaniasis affecting the digestive tract and causing malabsorption syndrome in a patient without recognized immunosuppressive condition. After appropriate treatment for the classical visceral form of the disease, diarrhea pe...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/240512 |
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| author | Gláucia Fernandes Cota Luciana Inácia Gomes Bruna Fernandes Pinto Joanna R. Santos-Oliveira Alda Maria Da-Cruz Moisés Salgado Pedrosa Wagner Luiz Tafuri Ana Rabello |
| author_facet | Gláucia Fernandes Cota Luciana Inácia Gomes Bruna Fernandes Pinto Joanna R. Santos-Oliveira Alda Maria Da-Cruz Moisés Salgado Pedrosa Wagner Luiz Tafuri Ana Rabello |
| author_sort | Gláucia Fernandes Cota |
| collection | DOAJ |
| description | This case report describes an atypical clinical presentation of visceral leishmaniasis affecting the digestive tract and causing malabsorption syndrome in a patient without recognized immunosuppressive condition. After appropriate treatment for the classical visceral form of the disease, diarrhea persisted as the main symptom and massive infection by Leishmania was detected by histopathology analysis of the duodenal mucosa. Schistosoma mansoni coinfection was also confirmed and treated without impact on diarrhea. New course of amphotericin B finally led to complete improvement of diarrhea. Atypical visceral leishmaniasis involving the gastrointestinal tract is well recognized in HIV coinfection but very rare in immunocompetent patients. The factors determining the control or evolution of the Leishmania infection have not been completely identified. This case stresses the importance of atypical symptoms and the unusual location of visceral leishmaniasis, not only in immunodepressed patients, and raises the possible influence of chronic infection by S. mansoni reducing the immune response to Leishmania. |
| format | Article |
| id | doaj-art-75a0697cce534eed9c448412fe74781e |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-75a0697cce534eed9c448412fe74781e2025-02-03T01:03:47ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/240512240512Dyarrheal Syndrome in a Patient Co-Infected with Leishmania infantum and Schistosoma mansoniGláucia Fernandes Cota0Luciana Inácia Gomes1Bruna Fernandes Pinto2Joanna R. Santos-Oliveira3Alda Maria Da-Cruz4Moisés Salgado Pedrosa5Wagner Luiz Tafuri6Ana Rabello7Hospital Eduardo de Menezes, Fundação Hospitalar do Estado de Minas Gerais (Fhemig), Rua Dr Cristiano Resende, 2213, 30622-020 Belo Horizonte, MG, BrazilLaboratório de Pesquisas Clínicas, Centro de Pesquisas René Rachou, Instituto Oswaldo Cruz-FIOCRUZ, Avenida Augusto de Lima, 1715, 30190-002 Belo Horizonte, MG, BrazilLaboratório de Pesquisas Clínicas, Centro de Pesquisas René Rachou, Instituto Oswaldo Cruz-FIOCRUZ, Avenida Augusto de Lima, 1715, 30190-002 Belo Horizonte, MG, BrazilLaboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz-FIOCRUZ, Avenida Brasil, 4365, 21040-360 Manguinhos, Rio de Janeiro, RJ, BrazilLaboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz-FIOCRUZ, Avenida Brasil, 4365, 21040-360 Manguinhos, Rio de Janeiro, RJ, BrazilHospital Eduardo de Menezes, Fundação Hospitalar do Estado de Minas Gerais (Fhemig), Rua Dr Cristiano Resende, 2213, 30622-020 Belo Horizonte, MG, BrazilDepartamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, 31270-901 Belo Horizonte, MG, BrazilLaboratório de Pesquisas Clínicas, Centro de Pesquisas René Rachou, Instituto Oswaldo Cruz-FIOCRUZ, Avenida Augusto de Lima, 1715, 30190-002 Belo Horizonte, MG, BrazilThis case report describes an atypical clinical presentation of visceral leishmaniasis affecting the digestive tract and causing malabsorption syndrome in a patient without recognized immunosuppressive condition. After appropriate treatment for the classical visceral form of the disease, diarrhea persisted as the main symptom and massive infection by Leishmania was detected by histopathology analysis of the duodenal mucosa. Schistosoma mansoni coinfection was also confirmed and treated without impact on diarrhea. New course of amphotericin B finally led to complete improvement of diarrhea. Atypical visceral leishmaniasis involving the gastrointestinal tract is well recognized in HIV coinfection but very rare in immunocompetent patients. The factors determining the control or evolution of the Leishmania infection have not been completely identified. This case stresses the importance of atypical symptoms and the unusual location of visceral leishmaniasis, not only in immunodepressed patients, and raises the possible influence of chronic infection by S. mansoni reducing the immune response to Leishmania.http://dx.doi.org/10.1155/2012/240512 |
| spellingShingle | Gláucia Fernandes Cota Luciana Inácia Gomes Bruna Fernandes Pinto Joanna R. Santos-Oliveira Alda Maria Da-Cruz Moisés Salgado Pedrosa Wagner Luiz Tafuri Ana Rabello Dyarrheal Syndrome in a Patient Co-Infected with Leishmania infantum and Schistosoma mansoni Case Reports in Medicine |
| title | Dyarrheal Syndrome in a Patient Co-Infected with Leishmania infantum and Schistosoma mansoni |
| title_full | Dyarrheal Syndrome in a Patient Co-Infected with Leishmania infantum and Schistosoma mansoni |
| title_fullStr | Dyarrheal Syndrome in a Patient Co-Infected with Leishmania infantum and Schistosoma mansoni |
| title_full_unstemmed | Dyarrheal Syndrome in a Patient Co-Infected with Leishmania infantum and Schistosoma mansoni |
| title_short | Dyarrheal Syndrome in a Patient Co-Infected with Leishmania infantum and Schistosoma mansoni |
| title_sort | dyarrheal syndrome in a patient co infected with leishmania infantum and schistosoma mansoni |
| url | http://dx.doi.org/10.1155/2012/240512 |
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