Hypertension Secondary to PHPT: Cause or Coincidence?
Primary hyperparathyroidism (PHPT) may be associated with arterial hypertension. The underlying mechanisms are not fully understood and reversibility by parathyroid surgery is controversial. This study aimed to characterize pressor hormones, vascular reactivity to norepinephrine, and cytosolic-free...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/974647 |
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| author | Helmut Schiffl Susanne M. Lang |
| author_facet | Helmut Schiffl Susanne M. Lang |
| author_sort | Helmut Schiffl |
| collection | DOAJ |
| description | Primary hyperparathyroidism (PHPT) may be associated with arterial hypertension. The underlying mechanisms are not fully understood and reversibility by parathyroid surgery is controversial. This study aimed to characterize pressor hormones, vascular reactivity to norepinephrine, and cytosolic-free calcium in platelets in 15 hypertensive patients with hypercalcaemic PHPT before and after successful parathyroidectomy and to compare them with 5 pre-hypertensive patients with normocalcaemic PHPT, 8 normotensive patients with hypercalcaemic PHPT and 15 normal controls. Hypertensive patients with hypercalcaemic PHPT had slightly higher levels of pressor hormones (𝑃<0.05), enhanced cardiovascular reactivity to norepinephrine (𝑃<0.05) and increased cytosolic calcium in platelets (𝑃<0.05) than controls. Pre-hypertensive patients with
normocalcaemic PHPT had intermediate values of increased
cardiovascular reactivity and cytosolic calcium. Normotensive
patients with hypercalcaemic PHPT and normotensive controls had
comparable pressor hormone concentrations and intracellular
calcium levels. Successful parathyroidectomy was associated with
normal blood pressure values and normalisation of pressor hormone
concentrations, cardiovascular pressor reactivity and cytosolic
free calcium. Our results suggest that parathyroid hypertension is
mediated/maintained, at least in part, by functional alterations
of vascular smooth muscle cells and can be cured by
parathyroidectomy in those patients who do not have primary
hypertension. |
| format | Article |
| id | doaj-art-759e115646e94a8e8f343c70bbb8a66e |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-759e115646e94a8e8f343c70bbb8a66e2025-08-20T03:35:27ZengWileyInternational Journal of Endocrinology1687-83371687-83452011-01-01201110.1155/2011/974647974647Hypertension Secondary to PHPT: Cause or Coincidence?Helmut Schiffl0Susanne M. Lang1Department of Internal Medicine-Campus Innenstadt, University Hospital, University of Munich, 80336 Munich, GermanyDepartment of Internal Medicine-Campus Innenstadt, University Hospital, University of Munich, 80336 Munich, GermanyPrimary hyperparathyroidism (PHPT) may be associated with arterial hypertension. The underlying mechanisms are not fully understood and reversibility by parathyroid surgery is controversial. This study aimed to characterize pressor hormones, vascular reactivity to norepinephrine, and cytosolic-free calcium in platelets in 15 hypertensive patients with hypercalcaemic PHPT before and after successful parathyroidectomy and to compare them with 5 pre-hypertensive patients with normocalcaemic PHPT, 8 normotensive patients with hypercalcaemic PHPT and 15 normal controls. Hypertensive patients with hypercalcaemic PHPT had slightly higher levels of pressor hormones (𝑃<0.05), enhanced cardiovascular reactivity to norepinephrine (𝑃<0.05) and increased cytosolic calcium in platelets (𝑃<0.05) than controls. Pre-hypertensive patients with normocalcaemic PHPT had intermediate values of increased cardiovascular reactivity and cytosolic calcium. Normotensive patients with hypercalcaemic PHPT and normotensive controls had comparable pressor hormone concentrations and intracellular calcium levels. Successful parathyroidectomy was associated with normal blood pressure values and normalisation of pressor hormone concentrations, cardiovascular pressor reactivity and cytosolic free calcium. Our results suggest that parathyroid hypertension is mediated/maintained, at least in part, by functional alterations of vascular smooth muscle cells and can be cured by parathyroidectomy in those patients who do not have primary hypertension.http://dx.doi.org/10.1155/2011/974647 |
| spellingShingle | Helmut Schiffl Susanne M. Lang Hypertension Secondary to PHPT: Cause or Coincidence? International Journal of Endocrinology |
| title | Hypertension Secondary to PHPT: Cause or Coincidence? |
| title_full | Hypertension Secondary to PHPT: Cause or Coincidence? |
| title_fullStr | Hypertension Secondary to PHPT: Cause or Coincidence? |
| title_full_unstemmed | Hypertension Secondary to PHPT: Cause or Coincidence? |
| title_short | Hypertension Secondary to PHPT: Cause or Coincidence? |
| title_sort | hypertension secondary to phpt cause or coincidence |
| url | http://dx.doi.org/10.1155/2011/974647 |
| work_keys_str_mv | AT helmutschiffl hypertensionsecondarytophptcauseorcoincidence AT susannemlang hypertensionsecondarytophptcauseorcoincidence |