Loss of adhesion impairs invasiveness and cell survival, contributing to the antimetastatic effect of cysteine proteases from Vasconcella cundinamarcensis in melanoma

Loss of adhesion impairs invasiveness and cell survival, contributing to the antimetastatic effect of cysteine proteases from Vasconcella cundinamarcensis in melanoma

Abstract Based on available evidence showing the antitumoral/antimetastatic activity of the proteolytic fraction (P1G10) from Vasconcellea cundinamarcensis, we analyze possible mechanisms involved in the antimetastasic effect of this fraction and subfractions (CMS1, CMS2) after incubation with B16F1...

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Bibliographic Details
Main Authors: Dalton Dittz, Isabela Paula Nunes, Hortência Maciel de Castro Oliveira, Gustavo Batista de Menezes, Carlos Edmundo Salas Bravo, Miriam Teresa Paz Lopes
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Metastasis
Melanoma
Cell adhesion
Cell invasion
Cysteine proteases
Online Access:https://doi.org/10.1038/s41598-024-73489-3
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