The Venom of Spectacled Cobra (Elapidae: Naja naja): In Vitro Study from Distinct Geographical Origins in Sri Lanka
Several countries residing envenomation due to Naja naja had revealed a disparity in the venom composition according to their geographic location and Sri Lankan cobra still lacks the evidence to support this. Therefore, the current study was focused on addressing relationship between the histopathol...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2018/7358472 |
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| author | Duminda S. B. Dissanayake Lasanthika D. Thewarage Roshitha N. Waduge J. G. S. Ranasinghe S. A. M. Kularatne R. P. V. Jayanthe Rajapakse |
| author_facet | Duminda S. B. Dissanayake Lasanthika D. Thewarage Roshitha N. Waduge J. G. S. Ranasinghe S. A. M. Kularatne R. P. V. Jayanthe Rajapakse |
| author_sort | Duminda S. B. Dissanayake |
| collection | DOAJ |
| description | Several countries residing envenomation due to Naja naja had revealed a disparity in the venom composition according to their geographic location and Sri Lankan cobra still lacks the evidence to support this. Therefore, the current study was focused on addressing relationship between the histopathological changes according to geographic variation of Sri Lankan N. naja venom. The histopathological changes in vital organs and muscle tissues following intramuscular administration of venom of N. naja were studied using BALB/c mice. The median lethal dose of venom of N. naja in the present study was determined to be 0.55, 0.66, 0.68, 0.62, and 0.7 mg/kg for North (NRP), Central (CRP), Western, Southern, and Sabaragamuwa Regional Population venoms, respectively. Histopathological changes were observed in different levels in vital organs and muscle tissues of mice. NRP accompanied significantly higher infiltration of inflammatory and necrotic cells into skeletal muscle and CRP venom demonstrated high level of cardiotoxic effects comparing to other regions. This study revealed a certain extent of variations in the pathological effects of N. naja venom samples according to their geographical distribution. |
| format | Article |
| id | doaj-art-75964237e1e04440bd2b8b2d9c984a2d |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-75964237e1e04440bd2b8b2d9c984a2d2025-08-20T03:35:22ZengWileyJournal of Toxicology1687-81911687-82052018-01-01201810.1155/2018/73584727358472The Venom of Spectacled Cobra (Elapidae: Naja naja): In Vitro Study from Distinct Geographical Origins in Sri LankaDuminda S. B. Dissanayake0Lasanthika D. Thewarage1Roshitha N. Waduge2J. G. S. Ranasinghe3S. A. M. Kularatne4R. P. V. Jayanthe Rajapakse5Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri LankaDepartment of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri LankaDepartment of Pathology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri LankaDepartment of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri LankaDepartment of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri LankaDepartment of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri LankaSeveral countries residing envenomation due to Naja naja had revealed a disparity in the venom composition according to their geographic location and Sri Lankan cobra still lacks the evidence to support this. Therefore, the current study was focused on addressing relationship between the histopathological changes according to geographic variation of Sri Lankan N. naja venom. The histopathological changes in vital organs and muscle tissues following intramuscular administration of venom of N. naja were studied using BALB/c mice. The median lethal dose of venom of N. naja in the present study was determined to be 0.55, 0.66, 0.68, 0.62, and 0.7 mg/kg for North (NRP), Central (CRP), Western, Southern, and Sabaragamuwa Regional Population venoms, respectively. Histopathological changes were observed in different levels in vital organs and muscle tissues of mice. NRP accompanied significantly higher infiltration of inflammatory and necrotic cells into skeletal muscle and CRP venom demonstrated high level of cardiotoxic effects comparing to other regions. This study revealed a certain extent of variations in the pathological effects of N. naja venom samples according to their geographical distribution.http://dx.doi.org/10.1155/2018/7358472 |
| spellingShingle | Duminda S. B. Dissanayake Lasanthika D. Thewarage Roshitha N. Waduge J. G. S. Ranasinghe S. A. M. Kularatne R. P. V. Jayanthe Rajapakse The Venom of Spectacled Cobra (Elapidae: Naja naja): In Vitro Study from Distinct Geographical Origins in Sri Lanka Journal of Toxicology |
| title | The Venom of Spectacled Cobra (Elapidae: Naja naja): In Vitro Study from Distinct Geographical Origins in Sri Lanka |
| title_full | The Venom of Spectacled Cobra (Elapidae: Naja naja): In Vitro Study from Distinct Geographical Origins in Sri Lanka |
| title_fullStr | The Venom of Spectacled Cobra (Elapidae: Naja naja): In Vitro Study from Distinct Geographical Origins in Sri Lanka |
| title_full_unstemmed | The Venom of Spectacled Cobra (Elapidae: Naja naja): In Vitro Study from Distinct Geographical Origins in Sri Lanka |
| title_short | The Venom of Spectacled Cobra (Elapidae: Naja naja): In Vitro Study from Distinct Geographical Origins in Sri Lanka |
| title_sort | venom of spectacled cobra elapidae naja naja in vitro study from distinct geographical origins in sri lanka |
| url | http://dx.doi.org/10.1155/2018/7358472 |
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