A Case of Glucocorticoid Remediable Aldosteronism and Thoracoabdominal Aneurysms
Glucocorticoid remediable aldosteronism (GRA) is rare familial form of primary aldosteronism characterized by a normalization of hypertension with the administration of glucocorticoids. We present a case of GRA and thoracoabdominal aneurysm complicated by multiple aortic dissections requiring comple...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/2017571 |
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| author | Anahita Shahrrava Sunnan Moinuddin Prajwal Boddu Rohan Shah |
| author_facet | Anahita Shahrrava Sunnan Moinuddin Prajwal Boddu Rohan Shah |
| author_sort | Anahita Shahrrava |
| collection | DOAJ |
| description | Glucocorticoid remediable aldosteronism (GRA) is rare familial form of primary aldosteronism characterized by a normalization of hypertension with the administration of glucocorticoids. We present a case of GRA and thoracoabdominal aneurysm complicated by multiple aortic dissections requiring complex surgical and endovascular repairs. Registry studies have shown a high rate of intracranial aneurysms in GRA patients with high case fatality rates. The association of thoracoabdominal aneurysms with GRA has not been described, thus far, in literature. Studies have shown that high tissue aldosterone levels concomitant with salt intake have a significant role in the pathogenesis of aneurysms and this may explain the formation of aneurysms in the intracranial vasculature and aorta. The association of GRA with thoracic aortic aneurysms needs to be further studied to develop screening recommendations for early identification and optimal treatment. Also, the early use of mineralocorticoid antagonists may have a significant preventive and attenuating effect in aneurysm formation, an association which needs to be confirmed in future studies. |
| format | Article |
| id | doaj-art-75952dd3dba543bebc0539bc5f7f448b |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-75952dd3dba543bebc0539bc5f7f448b2025-08-20T03:35:22ZengWileyCase Reports in Endocrinology2090-65012090-651X2016-01-01201610.1155/2016/20175712017571A Case of Glucocorticoid Remediable Aldosteronism and Thoracoabdominal AneurysmsAnahita Shahrrava0Sunnan Moinuddin1Prajwal Boddu2Rohan Shah3Department of Internal Medicine, Advocate Illinois Masonic Medical Center, 836 West Wellington Avenue, Chicago, IL 60657, USADepartment of Internal Medicine, Advocate Illinois Masonic Medical Center, 836 West Wellington Avenue, Chicago, IL 60657, USADepartment of Internal Medicine, Advocate Illinois Masonic Medical Center, 836 West Wellington Avenue, Chicago, IL 60657, USADepartment of Radiology, Advocate Illinois Masonic Medical Center, 836 West Wellington Avenue, Chicago, IL 60657, USAGlucocorticoid remediable aldosteronism (GRA) is rare familial form of primary aldosteronism characterized by a normalization of hypertension with the administration of glucocorticoids. We present a case of GRA and thoracoabdominal aneurysm complicated by multiple aortic dissections requiring complex surgical and endovascular repairs. Registry studies have shown a high rate of intracranial aneurysms in GRA patients with high case fatality rates. The association of thoracoabdominal aneurysms with GRA has not been described, thus far, in literature. Studies have shown that high tissue aldosterone levels concomitant with salt intake have a significant role in the pathogenesis of aneurysms and this may explain the formation of aneurysms in the intracranial vasculature and aorta. The association of GRA with thoracic aortic aneurysms needs to be further studied to develop screening recommendations for early identification and optimal treatment. Also, the early use of mineralocorticoid antagonists may have a significant preventive and attenuating effect in aneurysm formation, an association which needs to be confirmed in future studies.http://dx.doi.org/10.1155/2016/2017571 |
| spellingShingle | Anahita Shahrrava Sunnan Moinuddin Prajwal Boddu Rohan Shah A Case of Glucocorticoid Remediable Aldosteronism and Thoracoabdominal Aneurysms Case Reports in Endocrinology |
| title | A Case of Glucocorticoid Remediable Aldosteronism and Thoracoabdominal Aneurysms |
| title_full | A Case of Glucocorticoid Remediable Aldosteronism and Thoracoabdominal Aneurysms |
| title_fullStr | A Case of Glucocorticoid Remediable Aldosteronism and Thoracoabdominal Aneurysms |
| title_full_unstemmed | A Case of Glucocorticoid Remediable Aldosteronism and Thoracoabdominal Aneurysms |
| title_short | A Case of Glucocorticoid Remediable Aldosteronism and Thoracoabdominal Aneurysms |
| title_sort | case of glucocorticoid remediable aldosteronism and thoracoabdominal aneurysms |
| url | http://dx.doi.org/10.1155/2016/2017571 |
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