In vitro models to study viral-induced asthma exacerbation: a short review for a key issue

Asthma is a heterogenous inflammatory bronchial disease involving complex mechanisms, several inflammatory pathways, and multiples cell-type networks. Bronchial inflammation associated to asthma is consecutive to multiple aggressions on epithelium, such as microbiologic, pollutant, and antigenic age...

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Main Authors: Rémi Pereira De Oliveira, Clément Droillard, Gilles Devouassoux, Manuel Rosa-Calatrava
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Allergy
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Online Access:https://www.frontiersin.org/articles/10.3389/falgy.2025.1530122/full
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author Rémi Pereira De Oliveira
Rémi Pereira De Oliveira
Rémi Pereira De Oliveira
Rémi Pereira De Oliveira
Clément Droillard
Clément Droillard
Clément Droillard
Clément Droillard
Gilles Devouassoux
Gilles Devouassoux
Gilles Devouassoux
Gilles Devouassoux
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
author_facet Rémi Pereira De Oliveira
Rémi Pereira De Oliveira
Rémi Pereira De Oliveira
Rémi Pereira De Oliveira
Clément Droillard
Clément Droillard
Clément Droillard
Clément Droillard
Gilles Devouassoux
Gilles Devouassoux
Gilles Devouassoux
Gilles Devouassoux
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
author_sort Rémi Pereira De Oliveira
collection DOAJ
description Asthma is a heterogenous inflammatory bronchial disease involving complex mechanisms, several inflammatory pathways, and multiples cell-type networks. Bronchial inflammation associated to asthma is consecutive to multiple aggressions on epithelium, such as microbiologic, pollutant, and antigenic agents, which are responsible for both T2 and non-T2 inflammatory responses and further airway remodeling. Because asthma physiopathology involves multiple crosstalk between several cell types from different origins (epithelial, mesenchymal, and immune cells) and numerous cellular effectors, no single and/or representative in vitro model is suitable to study the overall of this disease. In this short review, we present and discuss the advantages and limitations of different in vitro models to decipher different aspects of virus-related asthma physiopathology and exacerbation.
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spelling doaj-art-75922d048e1644d2992ec4c9f5fe18b02025-08-20T02:48:42ZengFrontiers Media S.A.Frontiers in Allergy2673-61012025-03-01610.3389/falgy.2025.15301221530122In vitro models to study viral-induced asthma exacerbation: a short review for a key issueRémi Pereira De Oliveira0Rémi Pereira De Oliveira1Rémi Pereira De Oliveira2Rémi Pereira De Oliveira3Clément Droillard4Clément Droillard5Clément Droillard6Clément Droillard7Gilles Devouassoux8Gilles Devouassoux9Gilles Devouassoux10Gilles Devouassoux11Manuel Rosa-Calatrava12Manuel Rosa-Calatrava13Manuel Rosa-Calatrava14Manuel Rosa-Calatrava15Manuel Rosa-Calatrava16CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Université de Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, FranceInternational Research Laboratory RESPIVIR France - Canada, Centre Hospitalier Universitaire de Québec- Université Laval, Québec, QC, CanadaInternational Research Laboratory RESPIVIR France – Canada, Centre International de Recherche en Infectiologie, Université de Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, FranceVirnext, Faculté de Médecine RTH Laennec, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, FranceCIRI, Centre International de Recherche en Infectiologie, Team VirPath, Université de Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, FranceInternational Research Laboratory RESPIVIR France - Canada, Centre Hospitalier Universitaire de Québec- Université Laval, Québec, QC, CanadaInternational Research Laboratory RESPIVIR France – Canada, Centre International de Recherche en Infectiologie, Université de Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, FranceVirnext, Faculté de Médecine RTH Laennec, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, FranceCIRI, Centre International de Recherche en Infectiologie, Team VirPath, Université de Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, FranceInternational Research Laboratory RESPIVIR France - Canada, Centre Hospitalier Universitaire de Québec- Université Laval, Québec, QC, CanadaInternational Research Laboratory RESPIVIR France – Canada, Centre International de Recherche en Infectiologie, Université de Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, FranceDepartment of Respiratory Diseases, CIERA, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon et CRISALIS/F-CRIN INSERM Network, Lyon, FranceCIRI, Centre International de Recherche en Infectiologie, Team VirPath, Université de Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, FranceInternational Research Laboratory RESPIVIR France - Canada, Centre Hospitalier Universitaire de Québec- Université Laval, Québec, QC, CanadaInternational Research Laboratory RESPIVIR France – Canada, Centre International de Recherche en Infectiologie, Université de Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, FranceVirnext, Faculté de Médecine RTH Laennec, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, FranceCentre de Recherche en Infectiologie du Centre Hospitalier Universitaire de Québec - Université Laval, Faculté de Médecine, Département de Pédiatrie de l’Université Laval, Québec, QC, CanadaAsthma is a heterogenous inflammatory bronchial disease involving complex mechanisms, several inflammatory pathways, and multiples cell-type networks. Bronchial inflammation associated to asthma is consecutive to multiple aggressions on epithelium, such as microbiologic, pollutant, and antigenic agents, which are responsible for both T2 and non-T2 inflammatory responses and further airway remodeling. Because asthma physiopathology involves multiple crosstalk between several cell types from different origins (epithelial, mesenchymal, and immune cells) and numerous cellular effectors, no single and/or representative in vitro model is suitable to study the overall of this disease. In this short review, we present and discuss the advantages and limitations of different in vitro models to decipher different aspects of virus-related asthma physiopathology and exacerbation.https://www.frontiersin.org/articles/10.3389/falgy.2025.1530122/fullasthmaviral infectionin vitro modelexacerbationphysiopathology
spellingShingle Rémi Pereira De Oliveira
Rémi Pereira De Oliveira
Rémi Pereira De Oliveira
Rémi Pereira De Oliveira
Clément Droillard
Clément Droillard
Clément Droillard
Clément Droillard
Gilles Devouassoux
Gilles Devouassoux
Gilles Devouassoux
Gilles Devouassoux
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
Manuel Rosa-Calatrava
In vitro models to study viral-induced asthma exacerbation: a short review for a key issue
Frontiers in Allergy
asthma
viral infection
in vitro model
exacerbation
physiopathology
title In vitro models to study viral-induced asthma exacerbation: a short review for a key issue
title_full In vitro models to study viral-induced asthma exacerbation: a short review for a key issue
title_fullStr In vitro models to study viral-induced asthma exacerbation: a short review for a key issue
title_full_unstemmed In vitro models to study viral-induced asthma exacerbation: a short review for a key issue
title_short In vitro models to study viral-induced asthma exacerbation: a short review for a key issue
title_sort in vitro models to study viral induced asthma exacerbation a short review for a key issue
topic asthma
viral infection
in vitro model
exacerbation
physiopathology
url https://www.frontiersin.org/articles/10.3389/falgy.2025.1530122/full
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