Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats
Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuropro...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/2120971 |
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| author | Naren Bao Di Dai |
| author_facet | Naren Bao Di Dai |
| author_sort | Naren Bao |
| collection | DOAJ |
| description | Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympatholytic qualities. The aim of this study was to establish whether DEX also offers protection against ischemia and reperfusion- (I/R-) induced AKI in rats. An intraperitoneal injection of DEX (25 μg/kg) was administered 30 min prior to the induction of I/R. The results indicate that in the I/R rats, DEX played a protective role by reducing the damage to the tubules and maintaining renal function. Furthermore, in response to I/R, the DEX treatment reduced the mRNA expression of TNF-α, IL-1β, IL-6, and MCP-1 in the kidney tissues and the serum levels of TNF-α, IL-1β, IL-6, and MCP-1. DEX also reduced the levels of oxidative stress and apoptosis in the tubular cells. These results indicate that in response to I/R kidney injury, DEX plays a protective role by inhibiting inflammation and tubular cell apoptosis, reducing the production of reactive oxygen species, and promoting renal function. |
| format | Article |
| id | doaj-art-758fb9253c124f43b8c93639012d42e4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-758fb9253c124f43b8c93639012d42e42025-08-20T03:35:27ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/21209712120971Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in RatsNaren Bao0Di Dai1Department of Anesthesiology, The First Hospital of China Medical University, 155 Nanjing North Street, Shenyang, ChinaDepartment of Laboratory Medicine, The First Hospital of China Medical University, 155 Nanjing North Street, Shenyang, ChinaAcute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympatholytic qualities. The aim of this study was to establish whether DEX also offers protection against ischemia and reperfusion- (I/R-) induced AKI in rats. An intraperitoneal injection of DEX (25 μg/kg) was administered 30 min prior to the induction of I/R. The results indicate that in the I/R rats, DEX played a protective role by reducing the damage to the tubules and maintaining renal function. Furthermore, in response to I/R, the DEX treatment reduced the mRNA expression of TNF-α, IL-1β, IL-6, and MCP-1 in the kidney tissues and the serum levels of TNF-α, IL-1β, IL-6, and MCP-1. DEX also reduced the levels of oxidative stress and apoptosis in the tubular cells. These results indicate that in response to I/R kidney injury, DEX plays a protective role by inhibiting inflammation and tubular cell apoptosis, reducing the production of reactive oxygen species, and promoting renal function.http://dx.doi.org/10.1155/2020/2120971 |
| spellingShingle | Naren Bao Di Dai Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats Mediators of Inflammation |
| title | Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats |
| title_full | Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats |
| title_fullStr | Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats |
| title_full_unstemmed | Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats |
| title_short | Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats |
| title_sort | dexmedetomidine protects against ischemia and reperfusion induced kidney injury in rats |
| url | http://dx.doi.org/10.1155/2020/2120971 |
| work_keys_str_mv | AT narenbao dexmedetomidineprotectsagainstischemiaandreperfusioninducedkidneyinjuryinrats AT didai dexmedetomidineprotectsagainstischemiaandreperfusioninducedkidneyinjuryinrats |